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在“Elsevier电子期刊”中，命中：24条，耗时：0.0489765 秒

在所有数据库中总计命中：12条

1.HDM-PAMPA to predict gastrointestinal absorption, binding percentage, equilibrium and kinetics constants with human serum albumin and using 2 end-point measurements

作者：Alban Bujard¹ ; Charlotte Petit¹ ; Pierre-Alain Carrupt ; Serge Rudaz ; Julie Schappler ; ^{julie.schappler@unige.ch}

关键词：Passive permeability ; PAMPA ; Gastrointestinal tract absorption ; Binding percentage ; Dissociation/association constants ; Dissociation/association microconstants ; Human serum albumin

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

2.BBB penetration-targeting physicochemical lead selection: Ecdysteroids as chemo-sensitizers against CNS tumors

作者：Judit Mü ; ller^a ; Ana Martins^b ; ¹ ; Jó ; zsef Csá ; bi^c ; Ferenc Fenyvesi^d ; Á ; rpá ; d Kö ; nczö ; l^a ; Attila Hunyadi^c ; ^e ; ^{hunyadi.a@pharm.u-szeged.hu} ; Gyö ; rgy T. Balogh^a ; ^{gy.balogh@richter.hu}

关键词：PAMPA-BBB ; Physicochemical profiling ; Lead selection ; Ecdysteroid ; Cancer ; Adjuvant ; Chemo-sensitization

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

3.Tuning the predictive capacity of the PAMPA-BBB model

作者：Judit Mü ; ller^a ; Katalin Ess艖^b ; Gerg艖 Dargó ; ^a ; Á ; rpá ; d Kö ; nczö ; l^c ; Gyö ; rgy T. Balogh^c ; ^{gy.balogh@richter.hu" class="auth_mail" title="E-mail the corresponding author}

关键词：BBB ; blood&ndash ; brain barrier ; CNS ; central nervous system ; Caco-2 ; human adenocarcinoma colonic cell line ; logBB ; log(brain-to-plasma total concentration ratio) ; MDCK ; Madin-Darby canine kidney cell line ; PBLE ; porcine brain lipid extract ; PAMPA ; parallel artificial membrane permeability assay ; Pe ; PAMPA effective permeability coefficient (cm/s) ; P-gp ; P-glycoprotein ; SRD ; sum of ranking differences ; TPSA ; topological polar surface area

刊名：European Journal of Pharmaceutical Sciences

出版年：2015

4.A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates

作者：Joana Bicker^a ; ^b ; Gilberto Alves^b ; ^c ; Ana Fortuna^a ; ^b ; Patrí ; cio Soares-da-Silva^d ; ^e ; Amí ; lcar Falcã ; o^a ; ^b ; ^{acfalcao@ff.uc.pt" class="auth_mail" title="E-mail the corresponding author} ; ^{acfalcao@uc.pt" class="auth_mail" title="E-mail the corresponding author}

关键词：Entacapone (PubChem CID ; 5281081) ; Eslicarbazepine acetate (PubChem CID ; 179344) ; Etamicastat (PubChem CID ; 10450387) ; S-licarbazepine (PubChem CID ; 114709) ; Nebicapone (PubChem CID ; 9838389) ; Nepicastat hydrochloride (PubChem CID ; 9840545) ; Opicapone (PubChem CID ; 76966913) ; Tolcapone (PubChem CID ; 4659569) ; Zamicastat (PubChem CID ; 25156755)

刊名：International Journal of Pharmaceutics

出版年：2016

5.Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer’s disease

作者：Wanli Pan^a ; Ke Hu^b ; Ping Bai^c ; Lintao Yu^a ; Qinge Ma^a ; Tao Li^a ; Xu Zhang^a ; Changzhong Chen^a ; Kelin Peng^a ; Wenmin Liu^a ; ^{liuwm1969@163.com" class="auth_mail" title="E-mail the corresponding author} ; Zhipei Sang^a ; ^{sangzhipei@163.com" class="auth_mail" title="E-mail the corresponding author}

关键词：AD ; Alzheimer&rsquo ; s disease ; AChE ; acetylcholinesterase ; BuChE ; butyrylcholinesterase ; Aβ ; β-amyloid peptide ; BBB ; blood&ndash ; brain barrier ; ACh ; acetylcholine ; MTDL ; multitarget-directed ligand ; EeAChE ; electric eel AChE ; CAS ; catalytic anionic site ; PAS ; peripheral anionic site ; ORAC-FL ; Oxygen Radicals Absorbance Capacity by Fluorescence ; ThT ; thioflavin T ; PAMPA-BBB ; parallel artificial membrane permeation assay of the blood&minus ; brain barrier

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

6.Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer’s disease based on the fusion of donepezil and melatonin

作者：Jin Wang ; Zhi-Min Wang ; Xue-Mei Li ; Fan Li ; Jia-Jia Wu ; Ling-Yi Kong ; ^{cpu_lykong@126.com" class="auth_mail" title="E-mail the corresponding author} ; Xiao-Bing Wang ; ^{xbwang@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：AchE ; Acetylcholinesterase ; BuChE ; Butyrylcholinesterase ; AD ; Alzheimer&rsquo ; s disease ; Aβ ; β-Amyloid ; CAS ; Catalytic anionic site ; PAS ; Peripheral anionic site ; BBB ; Blood&ndash ; brain barrier ; AβOs ; Soluble Aβ oligomers ; CNS ; Central nervous system ; NFTS ; Neurofibrillary tangles ; ChEs ; Cholinesterases ; ChEIs ; Cholinesterase inhibitors ; CDI ; 1 ; 1&prime ; -Carbonyldiimidazole ; ORAC ; Oxygen radical absorbance capacity ; PAMPA ; Parallel artificial membrane permeation assay

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

7.Synthesis of a selective HDAC6 inhibitor active in neuroblasts

作者：Vincent Zwick^a ; Claudia A. Simõ ; es-Pires^a ; Alessandra Nurisso^a ; ^b ; Charlotte Petit^a ; Carolina Dos Santos Passos^a ; Giuseppe Marco Randazzo^a ; Nadine Martinet^c ; Philippe Bertrand^d ; ^e ; Muriel Cuendet^a ; ^{muriel.cuendet@unige.ch" class="auth_mail" title="E-mail the corresponding author}

关键词：Histone deacetylases ; Isoform selectivity ; HDAC6 ; PAMPA ; Neuroblastoma cells

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

8.Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets

作者：Jakub Chlebek^a ; ^{jakub.chlebek@faf.cuni.cz" class="auth_mail" title="E-mail the corresponding author} ; Angela De Simone^b ; Anna Ho&scaron ; ťá ; lková ; ^a ; Lubomí ; r Opletal^a ; Concepció ; n Pé ; rez^c ; Daniel I. Pé ; rez^d ; Lucie Havlí ; ková ; ^e ; Lucie Cahlí ; ková ; ^a ; Vincenza Andrisano^b

关键词：Canadine (PubChem CID ; 443422) ; Corycavamine (PubChem CID ; 90478581) ; Corynoline (PubChem CID ; 177014) ; Corycavidine (PubChem CID ; 12304033) ; Canadaline (PubChem CID ; 321459) ; Allocryptopine (PubChem CID ; 98570) ; Isocorypalmine (PubChem CID ; 10220) ; Corypalmine (PubChem CID ; 12304090) ; Scoulerine (PubChem CID ; 22955)

刊名：Fitoterapia

出版年：2016

9.Cyclosporine A kinetics in brain cell cultures and its potential of crossing the blood-brain barrier

作者：P. Bellwon^a ; ¹ ; ^{patricia.bellwon@uni-wuerzburg.de" class="auth_mail" title="E-mail the corresponding author} ; ^{patricia.bellwon@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; M. Culot^b ; ^c ; ¹ ; A. Wilmes^d ; ¹ ; T. Schmidt^a ; ¹ ; M.G. Zurich^e ; ¹ ; L. Schultz^f ; ¹ ; O. Schmal^a ; A. Gramowski-Voss^f ; D.G. Weiss^f ; P. Jennings^d ; A. Bal-Price^g ; E. Testai^h ; W. Dekant^a

关键词：CsA ; Cyclosporine A ; Cyp-B ; cyclophilin B ; BBB ; blood&ndash ; brain barrier ; LY ; lucifer yellow ; TC10 ; 10% toxic concentration ; AB ; apical-to-basolateral ; BA ; basolateral-to-apical ; PAMPA ; parallel artificial membrane assay ; PK ; pharmacokinetics ; CNS ; central nervous system ; EC ; endothelial cells

刊名：Toxicology in Vitro

出版年：2015

10.PAMPA study of the temperature effect on permeability

作者：G谩bor Vizser谩lek ; Tam谩s Balogh ; Krisztina Tak谩cs-Nov谩k ; B谩lint Sink贸

关键词：Temperature dependence ; Permeability ; Artificial membrane permeability assay ; Skin PAMPA&trade

刊名：European Journal of Pharmaceutical Sciences

出版年：12 March, 2014

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