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在“Elsevier电子期刊”中，命中：928条，耗时：0.0129912 秒

在所有数据库中总计命中：2,247条

1.Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase

作者：Kyle Parcella^a ; ¹ ; ^{kyle.parcella@bms.com} ; Andrew Nickel^a ; ¹ ; ² ; Brett R. Beno^a ; Steven Sheriff^b ; Changhong Wan^b ; ³ ; Ying-Kai Wang^a ; Susan B. Roberts^a ; Nicholas A. Meanwell^a ; John F. Kadow^a ; ⁴

关键词：Hepatitis C virus (HCV) ; NS5B polymerase ; Allosteric inhibitors ; Primer grip

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

2.Novel methods for the synthesis of 1,5,2-diazaphosphinines as potential inhibitors of HCV polymerase

作者：Daniel Da Costa^a ; ^{daniel.da.costa@merck.com} ; Arlè ; ne Roland^b ; Cyril B. Dousson^a

关键词：Hepatitis C virus ; 15 ; 2-Diazaphosphinines ; NS5B non-nucleoside inhibitors ; Thiadiazine bioisostere ; Allosteric inhibitors

刊名：Tetrahedron Letters

出版年：2017

3.Detection of Occult Hepatitis C Virus Infection in Patients Who Achieved a Sustained Virologic Response to Direct-Acting Antiviral Agents for Recurrent Infection After Liver Transplantation

作者：Sandra Elmasry¹ ; Sanya Wadhwa¹ ; Bo-Ram Bang¹ ; Linda Cook² ; ³ ; Shefali Chopra⁴ ; Gary Kanel⁴ ; Brian Kim¹ ; Tammy Harper¹ ; Zongdi Feng⁵ ; Keith R. Jerome² ; ³ ; Jeffrey A. Kahn¹ ; ^§ ; ; ^{jkahn@usc.edu} ; Takeshi Saito¹ ; ⁴ ; ⁶ ; ^§ ; ; ^{saitotak@usc.edu}

关键词：Viral Hibernation ; Treatment Outcome ; Persistence ; Limit of Detection

刊名：Gastroenterology

出版年：2017

4.Therapeutic potential of Taraxacum officinale against HCV NS5B polymerase: In-vitro and In silico study

作者：Sidra Rehman^a ; ^{sidrarehman@ciit.net.pk" class="auth_mail" title="E-mail the corresponding author} ; ^{sidra.cemb@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Bushra Ijaz^b ; Nighat Fatima^c ; Syed Aun Muhammad^d ; Sheikh Riazuddin^e

关键词：HCV ; Hepatitis C virus ; TM ; Taraxacum Officinale ; MOE ; Molecular operator Environment ; Huh-7 ; Human Hepatoma cell line ; CHO ; Chinese Hamster Ovarian cells

刊名：Biomedicine & Pharmacotherapy

出版年：2016

5.Design, synthesis, assessment, and molecular docking of novel pyrrolopyrimidine (7-deazapurine) derivatives as non-nucleoside hepatitis C virus NS5B polymerase inhibitors

作者：Mosaad S. Mohamed^a ; Amira I. Sayed^a ; Mohammed A. Khedr^b ; Sameh H. Soror^c ; ^d ; ^{sameh_soror@pharm.helwan.edu.eg" class="auth_mail" title="E-mail the corresponding author}

关键词：Antiviral drugs ; HCV ; Molecular modeling ; NS5B polymerase ; Pyrrolopyrimidine

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

6.Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase

作者：Claire Pierra Rouviè ; re^a ; ^{claire.pierra-rouviere@merck.com" class="auth_mail" title="E-mail the corresponding author} ; Agnè ; s Amador^b ; Eric Badaroux^b ; Thierry Convard^a ; Daniel Da Costa^a ; David Dukhan^a ; Ludovic Griffe^b ; Jean-Franç ; ois Griffon^a ; Massimiliano LaColla^c ; Fré ; dé ; ric Leroy^b ; Michel Liuzzi^d ; Anna Giulia Loi^d ; Joe McCarville^c ; Valeria Mascia^d ; Julien Milhau^a ; Loredana Onidi^d ; Jean-Laurent Paparin^a ; Rachid Rahali^a ; Efisio Sais^d ; Maria Seifer^c ; Dominique Surleraux^b ; David Standring^c ; Cyril Dousson^a

关键词：Hepatitis C virus ; Direct-acting antivirals ; NS5B non-nucleoside inhibitors ; Polymerase inhibitors ; Amide bioisostere ; Allosteric inhibitors

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

7.Structure-based optimization and derivatization of 2-substituted quinolone-based non-nucleoside HCV NS5B inhibitors with submicromolar cellular replicon potency

作者：Yu Cheng^a ; ^&dagger ; ; Jian Shen^b ; ^&dagger ; ; Run-Ze Peng^a ; Gui-Feng Wang^b ; Jian-Ping Zuo^b ; ^{jpzuo@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Ya-Qiu Long^a ; ^{yqlong@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：HCV NS5B polymerase ; 2-Alkyl quinolone ; 1 ; 6-Naphthyridine-4 ; 5-dione ; Non-nucleoside inhibitor ; Direct acting antiviral ; Allosteric site

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

8.Allosteric inhibitors of Coxsackie virus A24 RNA polymerase

作者：Catherine H. Schein^a ; ^b ; ^{chschein@ffame.org" class="auth_mail" title="E-mail the corresponding author} ; Diane Rowold^a ; Kyung H. Choi^b ; ^c

关键词：3Dpol ; enterovirus RNA polymerase ; cleaved from the 3rd viral protein ; 3ABCD ; where 3B is VPg and 3D the polymerase ; BE ; binding energy ; CVA ; Coxsackie virus A ; DENV ; Dengue virus (a flavivirus that does not use protein priming) ; EV ; enterovirus ; HCV ; hepatitis C virus ; PB ; polymerase buffer ; PV ; poliovirus ; RdRp ; RNA dependent RNA polymerase ; SDF ; structure data file ; VPg ; viral protein linked to the genome ; VPgpU ; uridylylated VPg ; polyU ; polyuridine

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

9.Efficacy and safety of ombitasvir/paritaprevir/r and dasabuvir compared to IFN-containing regimens in genotype 1 HCV patients: The MALACHITE-I/II trials

作者：Gregory J. Dore¹ ; ^&dagger ; ; ^{gdore@kirby.unsw.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Brian Conway² ; ^&dagger ; ; Yan Luo³ ; Ewa Janczewska⁴ ; Brygida Knysz⁵ ; Yan Liu³ ; Adrian Streinu-Cercel⁶ ; Florin Alexandru Caruntu⁷ ; Manuela Curescu⁸ ; Richard Skoien⁹ ; Wayne Ghesquiere¹⁰ ; Włodzimierz Mazur¹¹ ; Alejandro Soza¹² ; Francisco Fuster¹³ ; Susan Greenbloom¹⁴ ; Adriana Motoc¹⁵ ; Victoria Arama⁶ ; David Shaw¹⁶ ; Istvan Tornai¹⁷ ; Joseph Sasadeusz¹⁸ ; Olav Dalgard¹⁹ ; Danielle Sullivan³ ; Xuan Liu³ ; Mudra Kapoor³ ; Andrew Campbell³ ; Thomas Podsadecki³

关键词：HCV ; hepatitis C virus ; GT ; genotype ; TPV ; telaprevir ; PegIFN ; pegylated interferon ; RBV ; ribavirin ; SVR ; sustained virologic response ; DAA ; direct-acting antiviral agents ; OBV ; ombitasvir ; PTV ; paritaprevir ; r ; ritonavir ; DSV ; dasabuvir ; IL28B ; interleukin 28B ; RNA ; ribonucleic acid ; MEMS ; Medication Event Monitoring System ; PCR ; polymerase chain reaction ; LLOQ ; lower limit of quantitation ; SF-36v2 ; Short Form&ndash ; 36 version 2 Health Survey ; PRO ; patient-reported outcome ; MCS ; mental componen

刊名：Journal of Hepatology

出版年：2016

10.Association of thrombogenic genes polymorphisms with hepatocellular carcinoma in HCV Egyptian patients

作者：Amr S. Hanafy^a ; Farag A. Alaa^a ; Mohamed H. Randa^b ; ^{randahussiny@yahoo.com" class="auth_mail" title="E-mail the corresponding author}

关键词：ANOVA ; Analysis of variance ; CIs ; Confidence intervals ; ORs ; Odds ratios ; PCR ; Polymerase chain reaction ; RFLP ; Restricted fragment length polymorphism ; HCV ; Hepatitis c virus ; HCC ; Hepatocellular carcinoma ; FVL ; Factor V Leiden ; TSP-1 ; Thrombospondin-1

刊名：Gene

出版年：2016

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