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在“Elsevier电子期刊”中，命中：222条，耗时：0.0239867 秒

在所有数据库中总计命中：408条

1.In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase

作者：Marcella Bassetto^a ; ^{bassettom@cardiff.ac.uk} ; Pieter Leyssen^b ; Johan Neyts^b ; Mark M. Yerukhimovich^c ; David N. Frick^c ; Matthew Courtney-Smith^a ; Andrea Brancale^a

关键词：Structure-based virtual screening ; HCV NS3-helicase ; Piperazine derivatives ; Anti-HCV activity ; NS3 helicase inhibitors

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Antiviral activities of selected antimalarials against dengue virus type 2 and Zika virus

作者：Anuradha Balasubramanian^a ; Tadahisa Teramoto^a ; Amol A. Kulkarni^b ; Apurba K. Bhattacharjee^a ; ^{ab3094@georgetown.edu} ; Radhakrishnan Padmanabhan^a ; ^{rp55@georgetown.edu}

关键词：In silico modeling ; Stereo-electronic profiles ; Molecular electrostatic potentials (MEPs) ; Renilla luciferase reporter replicon ; Autophagy ; Cathepsin B

刊名：Antiviral Research

出版年：2017

3.Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV

作者：Marcella Bassetto^a ; ^{bassettom@cardiff.ac.uk} ; Pieter Leyssen^b ; Johan Neyts^b ; Mark M. Yerukhimovich^c ; David N. Frick^c ; Andrea Brancale^a

关键词：Ligand-based virtual screening ; Shape-similarity search ; Novel pyrrolones ; Anti-HCV activity

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

4.Novel diversity-oriented synthesis-derived respiratory syncytial virus inhibitors identified via a high throughput replicon-based screen

作者：Jeremy R. Duvall^a ; Lynn VerPlank^a ; Barbara Ludeke^b ; Sarah M. McLeod^c ; Maurice D. Lee IV^a ; Karthick Vishwanathan^d ; Carol A. Mulrooney^a ; Sebastian Le Quement^a ; Qin Yu^c ; Michelle A. Palmer^a ; Paul Fleming^c ; Rachel Fearns^b ; Michael A. Foley^a ; Christina A. Scherer^a ; ^{cscherer@alum.mit.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Respiratory syncytial virus ; Replicon ; Diversity-oriented synthesis

刊名：Antiviral Research

出版年：2016

5.Zika Virus Replicons for Drug Discovery

作者：Xuping Xie^a ; Jing Zou^a ; Chao Shan^a ; Yujiao Yang^a ; ^c ; Dieudonné ; Buh Kum^a ; ^d ; Kai Dallmeier^d ; Johan Neyts^d ; Pei-Yong Shi^a ; ^b ; ^{peshi@utmb.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Zika ; Drug discovery ; Replicon ; Flavivirus

刊名：EBioMedicine

出版年：2016

6.High-throughput screening for the identification of small-molecule inhibitors of the flaviviral protease

作者：Anuradha Balasubramanian¹ ; Mark Manzano¹ ; ² ; Tadahisa Teramoto ; Rajendra Pilankatta³ ; Radhakrishnan Padmanabhan ; ^{rp55@georgetown.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Protease inhibitors ; High-throughput screening ; Renilla luciferase reporter replicon ; Virus infectivity assays ; Therapeutic index ; Fluorescence quenching

刊名：Antiviral Research

出版年：2016

7.Structure-based optimization and derivatization of 2-substituted quinolone-based non-nucleoside HCV NS5B inhibitors with submicromolar cellular replicon potency

作者：Yu Cheng^a ; ^&dagger ; ; Jian Shen^b ; ^&dagger ; ; Run-Ze Peng^a ; Gui-Feng Wang^b ; Jian-Ping Zuo^b ; ^{jpzuo@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Ya-Qiu Long^a ; ^{yqlong@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：HCV NS5B polymerase ; 2-Alkyl quinolone ; 1 ; 6-Naphthyridine-4 ; 5-dione ; Non-nucleoside inhibitor ; Direct acting antiviral ; Allosteric site

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

8.Design, synthesis and biological evaluation of pyrido[2,3-d]pyrimidin-7-(8H)-ones as HCV inhibitors

关键词：Hepatitis C ; HCV genotype 1b replicon ; Small molecule inhibitor ; Pyrido[2 ; 3-d]pyrimidin-7-(8H)-ones

刊名：European Journal of Medicinal Chemistry

出版年：2016

9.Discovery of fluorobenzimidazole HCV NS5A inhibitors

作者：John T. Randolph ; Charles A. Flentge ; Pamela Donner ; Todd W. Rockway ; Sachin V. Patel ; Lissa Nelson ; Douglas K. Hutchinson ; Rubina Mondal ; Neeta Mistry ; Thomas Reisch ; Tatyana Dekhtyar ; Preethi Krishnan ; Tami Pilot-Matias ; Deanne F. Stolarik ; David W.A. Beno ; Rolf Wagner ; Clarence Maring ; Warren M. Kati

关键词：HCV ; NS5A inhibitor ; Antiviral

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

10.Structure-activity relationships of proline modifications around the tetracyclic-indole class of NS5A inhibitors

作者：Ling Tong^a ; ^{ling.tong@merck.com" class="auth_mail" title="E-mail the corresponding author} ; Wensheng Yu^a ; Craig A. Coburn^a ; Lei Chen^a ; Oleg Selyutin^a ; Qingbei Zeng^a ; Michael P. Dwyer^a ; Anilkumar G. Nair^a ; Bandarpalle B. Shankar^a ; Seong Heon Kim^a ; De-Yi Yang^a ; Stuart B. Rosenblum^a ; Rebecca T. Ruck^a ; Ian W. Davies^a ; Bin Hu^b ; Bin Zhong^b ; Jinglai Hao^b ; Tao Ji^b ; Shuai Zan^b ; Rong Liu^a ; Sony Agrawal^a ; Donna Carr^a ; Stephanie Curry^a ; Patricia McMonagle^a ; Karin Bystol^a ; Frederick Lahser^a ; Paul Ingravallo^a ; Shiying Chen^a ; Ernest Asante-Appiah^a ; Joseph A. Kozlowski^a

关键词：HCV NS5A inhibitor ; Elbasvir ; MK-8742 ; Direct-acting antiviral agents ; HCV infection treatment ; Indole based tetracyclic core

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

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