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在“Elsevier电子期刊”中，命中：30条，耗时：0.129932 秒

在所有数据库中总计命中：77条

1.Open-label therapy with alirocumab in patients with heterozygous familial hypercholesterolemia: Results from three years of treatment

作者：Robert Dufour^a ; ^{robert.dufour@ircm.qc.ca} ; Jean Bergeron^b ; Daniel Gaudet^c ; Robert Weiss^d ; G. Kees Hovingh^e ; Zhizhi Qing^f ; Feng Yang^g ; Matthew Andisik^g ; Albert Torri^g ; Robert Pordy^g ; Daniel A. Gipe^g

关键词：AE ; adverse event ; Apo ; apolipoprotein ; CVD ; cardiovascular disease ; HDL-C ; high-density lipoprotein cholesterol ; HeFH ; heterozygous familial hypercholesterolemia ; LDL-C ; low-density lipoprotein cholesterol ; Lp(a) ; lipoprotein (a) ; LLT ; lipid-lowering therapy ; MedDRA ; Medical Dictionary for Regulatory Activities ; MI ; myocardial infarction ; PCSK9 ; proprotein convertase subtilisin/kexin type 9 ; Q2W ; every 2 ; weeks ; Q4W ; every 4 ; weeks ; SD ; standard deviation ; TEAE ; treatment-emergent adver

刊名：International Journal of Cardiology

出版年：2017

2.Local Side Effects of Sublingual and Oral Immunotherapy

作者：Giovanni Passalacqua ; MD^a ; ^{passalacqua@unige.it} ; Anna Nowak-Węgrzyn ; MD^b ; Giorgio Walter Canonica ; MD^a

关键词：Sublingual immunotherapy ; Oral desensitization ; Respiratory allergy ; Food allergy ; Safety ; Oral immunotherapy ; Adverse events ; Local side effects

刊名：The Journal of Allergy and Clinical Immunology: In Practice

出版年：2017

3.Safety and tolerability profile of daclizumab in patients with relapsing-remitting multiple sclerosis: An integrated analysis of clinical studies

关键词：AE ; adverse event ; ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; DRESS ; drug reaction with eosinophilia and systematic symptoms ; DSMB ; data safety monitoring board ; GGT ; gamma-glutamyl transferase ; GI ; gastrointestinal ; IL-2 ; interleukin 2 ; IM ; intramuscular ; MedDRA ; Medical Dictionary for Regulatory Activities ; MS ; multiple sclerosis ; RRMS ; relapsing-remitting multiple sclerosis ; SAE ; serious adverse event ; SMQ ; Standardised MedDRA Query ; SOC ; System Organ Class ; ULN ; upper li

刊名：Multiple Sclerosis and Related Disorders

出版年：2016

4.A randomized, double-blind, phase II study of ramucirumab plus docetaxel vs placebo plus docetaxel in Japanese patients with stage IV non-small cell lung cancer after disease progression on platinum-based therapy

作者：Kiyotaka Yoh ; MD^a ; ^{kyoh@east.ncc.go.jp" class="auth_mail" title="E-mail the corresponding author} ; Yukio Hosomi ; MD PhD^b ; Kazuo Kasahara ; MD PhD^c ; Kazuhiko Yamada ; MD PhD^d ; Toshiaki Takahashi ; MD^e ; Nobuyuki Yamamoto ; MD PhD^f ; Makoto Nishio ; MD PhD^g ; Yuichiro Ohe ; MD PhD^h ; Toshiko Koue ; PhDⁱ ; Takashi Nakamura ; MPHⁱ ; Sotaro Enatsu ; MD PhDⁱ ; Pablo Lee ; MD^j ; David Ferry ; PhD^j ; Tomohide Tamura ; MD^k ; Kazuhiko Nakagawa ; MD PhD^l

关键词：AE ; adverse event ; CI ; confidence interval ; CR ; complete response ; CT ; computed tomography ; DCR ; disease control rate ; ECOG ; Eastern Cooperative Oncology Group ; EGFR ; epidermal growth factor receptor ; FAS ; full analysis set ; HR ; hazard ratio ; ILD ; interstitial lung disease ; IRRC ; Independent Response Review Committee ; MedDRA ; medical dictionary for regulatory activities ; MRI ; magnetic resonance imaging ; NCI-CTCAE ; national cancer institute-common terminology criteria for adverse events ; NSCLC ; n

刊名：Lung Cancer

出版年：2016

5.Long-term efficacy and safety of intramuscular interferon beta-1a: Randomized postmarketing trial of two dosing regimens in Japanese patients with relapsing-remitting multiple sclerosis

作者：Takahiko Saida^a ; ^{Saida_takahiko@maia.eonet.ne.jp" class="auth_mail" title="E-mail the corresponding author} ; Jun-ichi Kira^b ; ^{kira@neuro.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Yasuhiro Ueno^c ; ^{yasuhiro.ueno@biogen.com" class="auth_mail" title="E-mail the corresponding author} ; Naozumi Harada^c ; ^{nysharad@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Toshiyuki Hirakata^c ; ^{toshiyuki.hirakata@biogen.com" class="auth_mail" title="E-mail the corresponding author}

关键词：ARR ; annualized relapse rate ; CI ; confidence interval ; EDSS ; Expanded Disability Status Scores ; Gd+ ; gadolinium-enhancing ; IFN beta ; interferon beta ; IFN beta-1a ; interferon beta-1a ; IM ; intramuscular ; MedDRA ; Medical Dictionary for Regulatory Activities ; MRI ; magnetic resonance imaging ; MS ; multiple sclerosis ; MSCRG ; Multiple Sclerosis Collaborative Research Group ; RRMS ; relapsing remitting multiple sclerosis ; SD ; standard deviation

刊名：Multiple Sclerosis and Related Disorders

出版年：2016

6.A randomized Phase 2 study of pemetrexed in combination with cisplatin or carboplatin as adjuvant chemotherapy in patients with completely resected stage IB or II Non-Small-Cell Lung Cancer

关键词：AE ; adverse event ; CTCAE ; common terminology criteria for adverse events ; CI ; confidence interval ; DFS ; disease-free survival ; IHC ; immunohistochemistry ; i.v. ; intravenous ; MedDRA ; medical dictionary for regulatory activities ; NSCLC ; Non-Small-Cell Lung Cancer ; OS ; overall survival ; SAE ; serious adverse event ; SNP ; single nucleotide polymorphism ; TEAE ; treatment emergent adverse event ; TREAT ; Trial on Refinement of Early stage lung cancer Adjuvant Therapy

刊名：Lung Cancer

出版年：2015

7.Construction and analysis of a human hepatotoxicity database suitable for QSAR modeling using post-market safety data

作者：Xiao Zhu ; Naomi L. Kruhlak ; ^{Naomi.Kruhlak@fda.hhs.gov" class="auth_mail}

关键词：DILIN ; Drug-Induced Liver Injury Network ; PDR ; Physician's Desk Reference ; AE ; adverse event ; FAERS ; FDA Adverse Event Reporting System ; ESignal ; Empirica Signal ; MGPS ; multi-item gamma-Poisson shrinker ; MedDRA ; Medical Dictionary for Regulatory Activities ; NW-EBGM ; N-weighted average empirical Bayes geometric mean ; SOC ; system organ class ; PT ; preferred term ; DRAE ; drug-related adverse effects ; BDD ; bile duct disorders ; LEA ; liver enzyme abnormalities ; CHOL ; cholestasis ; LD ; liver damage ; CT ; c

刊名：Toxicology

出版年：3 July 2014

8.AXT914 a novel, orally-active parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women

作者：Markus R. John^a ; Evita Harfst^a ; Juergen Loeffler^a ; Rossella Belleli^a ; June Mason^a ; Gerard J.M. Bruin^b ; Klaus Seuwen^b ; Lloyd B. Klickstein^b ; Linda Mindeholm^a ; Leo Widler^b ; Michaela Kneissel^b ; ^{michaela.kneissel@novartis.com" class="auth_mail}

关键词：AE ; adverse event ; ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; AUCtau ; area under the time versus blood level curve in one dosing interval ; BMD ; bone mineral density ; CaSR ; calcium-sensing receptor ; Cmax ; maximum (peak) concentration ; CPK ; creatine phosphokinase ; CTX-I ; C-terminal cross-linked telopeptide of Type I collagen ; GCP ; good clinical practice ; LLN ; lower limit of normal ; MedDRA ; medical dictionary for regulatory activities ; PD ; pharmacodynamic(s) ; PIP ; Type I procol

刊名：Bone

出版年：July 2014

9.Sapropterin dihydrochloride use in pregnant women with phenylketonuria: An interim report of the PKU MOMS sub-registry

作者：Dorothy K. Grange^a ; Richard E. Hillman^b ; Barbara K. Burton^c ; Shoji Yano^d ; Jerry Vockley^e ; ^h ; Chin-To Fong^f ; JoEllen Hunt^g ; John J. Mahoney^g ; Jessica L. Cohen-Pfeffer^g ; ^{JCohen@bmrn.com" class="auth_mail} ; On behalf of the Phenylketonuria Demographics Outcomes ; Safety (PKUDOS) registry

关键词：AE ; adverse event ; Apgar ; Appearance ; Pulse ; Grimace ; Activity ; Respiration ; BH4 ; tetrahydrobiopterin ; BMI ; Body Mass Index ; CDC ; Centers for Disease Control and Prevention ; ID ; identification ; LMP ; last menstrual period ; OFC ; occipitofrontal circumference ; PAH ; phenylalanine hydroxylase ; Phe ; phenylalanine ; PKU MOMS ; Maternal Phenylketonuria Observational Program ; MedDRA ; Medical Dictionary for Regulatory Activities ; PKU ; phenylketonuria ; PKUDOS ; Phenylketonuria Demographics Outcomes and Safety

刊名：Molecular Genetics and Metabolism

出版年：May 2014

10.Boceprevir for chronic HCV genotype 1 infection in patients with prior treatment failure to peginterferon/ribavirin, including prior null response

作者：John M. Vierling¹ ; ^{vierling@bcm.tmc.edu" class="auth_mail} ; Mitchell Davis² ; Steven Flamm³ ; Stuart C. Gordon⁴ ; Eric Lawitz⁵ ; Eric M. Yoshida⁶ ; Joseph Galati⁷ ; Velimir Luketic⁸ ; Jonathan McCone⁹ ; Ira Jacobson¹⁰ ; Patrick Marcellin¹¹ ; Andrew J. Muir¹² ; Fred Poordad⁵ ; Lisa D. Pedicone¹³ ; ^&dagger ; ; Janice Albrecht¹³ ; ^&dagger ; ; Clifford Brass¹³ ; ^&dagger ; ; Anita Y.M. Howe¹³ ; Lynn Y. Colvard¹³ ; Frans A. Helmond¹³ ; Weiping Deng¹³ ; Michelle Treitel¹³ ; ^&dagger ; ; Janice Wahl¹³ ; Jean-Pierre Bronowicki¹⁴

关键词：HCV ; hepatitis C virus ; BOC ; boceprevir ; PR ; peginterferon with ribavirin ; SVR ; sustained virological response ; TW ; treatment week ; NS3/4A ; nonstructural proteins 3 and 4A ; IU/ml ; international units per milliliter ; mITT ; modified intent-to-treat ; ITT ; intent-to-treat ; FW ; follow-up week ; MedDRA ; Medical Dictionary for Regulatory Activities ; WHO ; World Health Organization ; FDA ; Food and Drug Administration ; RAV ; resistance associated variant

刊名：Journal of Hepatology

出版年：April, 2014

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