金匮肾气丸对“恐伤肾”模型仔鼠皮质酮水平的调节作用
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摘要
目的:观察金匮肾气丸对恐伤孕鼠孕仔数及仔鼠体质、血清皮质酮(CORT)水平的影响。方法:采用模拟地震的生物学实验,造成"恐惧"心理应激,建立"恐伤肾"模型,观察孕鼠每胎孕仔数、仔鼠体重、翻身能力及CORT水平。结果:中药金匮肾气丸能显著提高"恐伤肾"孕鼠的孕仔数(P<0.01),增加仔鼠平均体重,提高仔鼠翻身能力(P<0.01),改善应激条件下仔鼠CORT水平的变化(P<0.01)。结论:中药金匮肾气丸可预防恐伤孕鼠肾精不足,同时通过对仔鼠CORT的调节,有效地改善仔鼠恐惧应激反应,具有良好的抗恐惧应激损伤作用。
Objective:To observe the influnce of Jinkui Shenqi Pill on the number of the terror leading to disorder of kidney pregnant rats and the serum level of corticosterone in the offsprings.Methods:Use the simulation of the earthquake biological experiment to cause terror psychological sress,the terror leading to disorder of kidney pregnant SD rats model was established,to observe the number of the pregnant rats,the weight,turning over ability and the serum corticosterone in the offsprings.Results:Jinkui Shenqi Pill can obviously improve the number of the pregnant rats with the terror damaging the kidney(P<0.01),increase the average weight of the offsprings,advance the offsprings' turning over ability(P<0.01),and improve the change of the offsprings' corticosterone level in the stress condition(P<0.01).Conclusion:Jinkui Shenqi Pill can prevent pregnant rats from damage due to terror which can lead to the kidney essence deficiency.At the same time it can regulate the offsprings' serum level of corticosterone,and effectively improve the offsprings' fear stress response to make them have a good resistance for the fear stress damage.
Objective:To observe the influnce of Jinkui Shenqi Pill on the number of the terror leading to disorder of kidney pregnant rats and the serum level of corticosterone in the offsprings.Methods:Use the simulation of the earthquake biological experiment to cause terror psychological sress,the terror leading to disorder of kidney pregnant SD rats model was established,to observe the number of the pregnant rats,the weight,turning over ability and the serum corticosterone in the offsprings.Results:Jinkui Shenqi Pill can obviously improve the number of the pregnant rats with the terror damaging the kidney(P<0.01),increase the average weight of the offsprings,advance the offsprings' turning over ability(P<0.01),and improve the change of the offsprings' corticosterone level in the stress condition(P<0.01).Conclusion:Jinkui Shenqi Pill can prevent pregnant rats from damage due to terror which can lead to the kidney essence deficiency.At the same time it can regulate the offsprings' serum level of corticosterone,and effectively improve the offsprings' fear stress response to make them have a good resistance for the fear stress damage.
引文
[1]印会河.中医基础理论[M].上海:上海科学技术出版社,1983:40.
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[3]吴敦序.中医基础理论[M].上海:上海科学技术出版社,1994.
[4]Lee W,Balasubramaniam M,Deter RL,et al.growth parameters andbirth weight:their relationship to neonatal body composition[J].Ultra-sound Obstet Gynecol,2009(27):123-125.
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[6]Wright NE.Breastfeeding the borderline(near term)preterm infant[J].Breastfeed Rev,2004,12(3):17-24.
[7]吴伟康,侯灿.电针“足三里”预防地塞米松引起肾上腺皮质萎缩的形态学研究[J].中西医结合杂志,1983,8(2):98-100.
[8]徐志伟.敖海清.严灿,等.逍遥散对慢性心理应激大鼠空间学习记忆力的影响[J].中国行为医学科学,2004,13(5):484-485.
[9]Bauerm,Perks P,Lightman SL,et al.Restraint stress is associated withchanges in glucocorticoid immunoregulation[J].Physiol Behav,2001,73(4):525-532.
[10]谢雯,杨东伟,王莹,等.应激对成年雌性大鼠血清皮质酮、甲状腺素及生长激素的影响[J].西安医科大学学报,2002,23(3):252-254.
[2]刘琴,张先庚,梁清芳,等.从SD大鼠子代的体重与身长论证优裕“胎教”和地震“胎损”环境的造模[J].辽宁中医药大学学报,2012,14(1):88-90.
[3]吴敦序.中医基础理论[M].上海:上海科学技术出版社,1994.
[4]Lee W,Balasubramaniam M,Deter RL,et al.growth parameters andbirth weight:their relationship to neonatal body composition[J].Ultra-sound Obstet Gynecol,2009(27):123-125.
[5]Vaag A.Low birth weight and early weight gain in the metabolic syn-drome:consequences for infant nutrition[J].Int J GynaecolObstet,2009,104(Suppl 1):32-34.
[6]Wright NE.Breastfeeding the borderline(near term)preterm infant[J].Breastfeed Rev,2004,12(3):17-24.
[7]吴伟康,侯灿.电针“足三里”预防地塞米松引起肾上腺皮质萎缩的形态学研究[J].中西医结合杂志,1983,8(2):98-100.
[8]徐志伟.敖海清.严灿,等.逍遥散对慢性心理应激大鼠空间学习记忆力的影响[J].中国行为医学科学,2004,13(5):484-485.
[9]Bauerm,Perks P,Lightman SL,et al.Restraint stress is associated withchanges in glucocorticoid immunoregulation[J].Physiol Behav,2001,73(4):525-532.
[10]谢雯,杨东伟,王莹,等.应激对成年雌性大鼠血清皮质酮、甲状腺素及生长激素的影响[J].西安医科大学学报,2002,23(3):252-254.
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