重大突发事件时机体主动应激与被动应激导致的代谢差异研究
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摘要
目的分析重大突发事件时机体主动应激与被动应激状态下所导致的机体代谢的差异,并讨论其影响因素。方法采集我院57名赴汶川抗震救灾医疗队队员和13名经历地震受灾群众清晨空腹血液标本,用日立Hitachi7600全自动生化分析仪检测肝功能、糖代谢及肾功能、血清酶类、血清离子、血清脂类等38项生化指标。并用CHISS软件分析所获得的数据。结果应激对血清生化指标具有不同程度的影响,与抗震救灾医疗队队员相比,受灾群众组ADA、ALP和TG明显升高,而TP、ALB、MAO、Cr、UA、K、Na、Cl、Ca、ApoA1和HDL等指标显著下降。结论两组血液样本的生化指标由于应激程度的不同呈现一定的变化趋势,并且主动应激情况下机体的各项功能及状况明显优于被动应激。
Objective To study the metabolic difference of body influenced by active stress and passive stress under special events. Methods To detect serum multiple biochemistry index of 57 earthquake rescue medical team and 13 victims of a natural calamity in Wenchuan earthquake by using Hitachi 7600 automatic analyzer. Results Stress affected biochemistry index deeply. To compared with rescue medical team, the serum ADA, ALP and TG of victims increased obviously and TP, ALB, MAO, Cr, UA, K, Na, Cl, Ca, ApoA1 and HDL decreased obviously. Conclusion Many biochemistry index have been changed under stress and it relate with stress extent. The human body function status was better in active stress than in passive stress.
Objective To study the metabolic difference of body influenced by active stress and passive stress under special events. Methods To detect serum multiple biochemistry index of 57 earthquake rescue medical team and 13 victims of a natural calamity in Wenchuan earthquake by using Hitachi 7600 automatic analyzer. Results Stress affected biochemistry index deeply. To compared with rescue medical team, the serum ADA, ALP and TG of victims increased obviously and TP, ALB, MAO, Cr, UA, K, Na, Cl, Ca, ApoA1 and HDL decreased obviously. Conclusion Many biochemistry index have been changed under stress and it relate with stress extent. The human body function status was better in active stress than in passive stress.
引文
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[2]Taylor HR,Freeman MK,Cates ME.Prazosin for treatment of nightmares related to posttraumatic stress disorder[J].Am J Health Syst Pharm,2008,65(8):716-22.
[3]刘永学,高月.应激研究进展[J].中国病理生理杂志,2002,18(2):218-21.
[4]贺岩松,姜丽华,张乐研.军事体能训练中应激损伤的适应性研究[J].临床军医杂志,2006,34(3):361-62.
[5]光吉博则.氧化应激的病理生理作用[J].日本医学介绍,2007,28(4):150-2.
[6]范立群,韦龙祥,彭鹰.糖尿病与氧化应激的研究进展[J].右江民族医学院学报,2007(4):629-31.
[7]袁杰.竹节人参皂甙对心肌缺血再灌注损伤保护作用的研究[J].中国民族医药杂志,2008(3):48-50.
[8]Clark VR,Moore CL,Adams JH.Cholesterol concentrations and cardiovascular reactivity to stress in African American college volunteers[J].J Behav Med,1998,21(5):505-15.
[9]McCann BS,Benjamin GA,Wilkinson CW,et al.Plasma lipid concentrations during episodic occupational stress[J].Ann Behav Med,1999,21(2):103-10.
[10]Chander R,Kapoor NK.High density lipoprotein is a scavenger of superoxide anions[J].Biochem Pharmacol,1990,40(7):1663-5.
[11]梁宝勇,刘畅,杜桂芝,等.择期性腹内手术病人的应激反应与心理准备的研究.Ⅲ.心理准备对病人术后身体恢复的影响[J].中国临床心理学杂志,1994,2(4):204-6.
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