Known unknowns of cardiolipin signaling: The best is yet to come

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• 作者：John J. Maguire^a ; ^b ; Yulia Y. Tyurina^a ; ^b ; Dariush Mohammadyani^a ; ^b ; Aleksandr A. Kapralov^a ; ^b ; Tamil S. Anthonymuthu^b ; ^c ; Feng Qu^a ; ^b ; Andrew A. Amoscato^a ; ^b ; Louis J. Sparvero^a ; ^b ; Vladimir A. Tyurin^a ; ^b ; Joan Planas-Iglesias^d ; Rong-Rong He^a ; ^b ; Judith Klein-Seetharaman^d ; Hü ; lya Bayır^a ; ^b ; ^c ; ^{bayihx@ccm.upmc.edu} ; Valerian E. Kagan^a ; ^b ; ^c ; ^e ; ^f ; ^g ; ^{kagan@pitt.edu}
• 关键词：AAPH ; (2 ; 2&prime ; -azobis-2-methyl-propanimidamide ; dihydrochloride) ; CL ; cardiolipin ; cyt c ; cytochrome c ; DAMPs ; danger-associated molecular patterns ; IMM ; inner mitochondria membrane ; IMS ; mitochondrial inter membrane space ; LC ; liquid chromatography ; MLCL ; monolyso-cardiolipin ; MS ; mass spectrometry ; NL ; neutral loss ; OMM ; outer mitochondrial membrane ; PA ; phosphatidic acid ; PAMP ; pathogen-associated molecular patterns ; PG ; phosphatidyl glycerol ; PS ; phosphatidylserine ; PUFA ; polyunsaturated
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1862
• 期：1
• 页码：8-24
• 全文大小：2801 K
• 卷排序：1862

文摘

Cardiolipin (CL) is a unique ancient lipid common to bacteria and mitochondria Cardiolipin is essential for mitochondrial bioenergetic functions While located in the inner membrane, CL can externalize and signal mitophagy Enzymatic oxidation of mitochondrial cardiolipins is required for apoptosis Oxidized CLs are precursors of lipid mediators and diversity of CL is tissue specific