介孔二氧化硅-阿维菌素缓释体系的制备与性能研究
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摘要
以正硅酸乙酯(TEOS)为硅源,氨水为碱性催化剂,采用无模板法制备介孔二氧化硅和中空介孔二氧化硅,选用持效期较短的阿维菌素作为模型药物构成缓释体系,通过扫描电镜(SEM)、透射电镜(TEM)、比表面仪(BET)、傅里叶红外光谱仪(FTIR)和紫外分光光度计(UV)对二氧化硅材料的形貌、粒径、载药量进行表征和测定,同时测试其缓释性能。探讨了溶剂蒸发法和超声浸渍法两种不同载药方法对缓释性能的影响。结果表明,两种农药缓释载体均呈球形,平均粒径500 nm,其中中空介孔二氧化硅载体具有独特的中空介孔复合结构,超声浸渍法载药效果较好,两种载体的载药量分别为48. 89%和52. 58%,中空介孔二氧化硅-阿维菌素缓释体系的缓释区间较大,缓释效果较好,31 h才基本达到平衡。
Using tetraethyl orthosilicate( TEOS) as the silicon source with ammonia as the basic catalyst,mesoporous silica and hollow mesoporous silica were prepared to the sustained release carrier of pesticide by template-free method. Abamectin with a short duration was used as a model drug to constitute a sustained-release system. The morphology,particle size and drug loading of the avermectin sustained release agent were characterized by SEM,TEM,BET,FTIR and UV,and the sustained release properties were tested by a drug dissolution apparatus. The effects on the sustained release properties of two different drug loading methods,including solvent evaporation and ultrasonic impregnation were discussed. The results showed that the two kinds of pesticide sustained-release carriers were spherical and the average particle size was 500 nm. The ultrasonic impregnation method had better drug-loading effect. The drug loading of the two carriers was 48. 89% and 52. 58%. Hollow mesoporous silica-avermectin sustained-release system has large sustained-release interval with good sustained-release effect. The equilibrium was basically reached at 31 h.
Using tetraethyl orthosilicate( TEOS) as the silicon source with ammonia as the basic catalyst,mesoporous silica and hollow mesoporous silica were prepared to the sustained release carrier of pesticide by template-free method. Abamectin with a short duration was used as a model drug to constitute a sustained-release system. The morphology,particle size and drug loading of the avermectin sustained release agent were characterized by SEM,TEM,BET,FTIR and UV,and the sustained release properties were tested by a drug dissolution apparatus. The effects on the sustained release properties of two different drug loading methods,including solvent evaporation and ultrasonic impregnation were discussed. The results showed that the two kinds of pesticide sustained-release carriers were spherical and the average particle size was 500 nm. The ultrasonic impregnation method had better drug-loading effect. The drug loading of the two carriers was 48. 89% and 52. 58%. Hollow mesoporous silica-avermectin sustained-release system has large sustained-release interval with good sustained-release effect. The equilibrium was basically reached at 31 h.
引文
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[2] Meyer W L,Gurman P,Stelinski L L,et al. Functional nano-dispensers(FNDs)for delivery of insecticides against phytopathogen vectors[J]. Green Chemistry,2015,17(8):4173-4177.
[3] C Lidong,Z Huirong,C Chong,et al. Quaternized chitosancapped mesoporous silica nanoparticles as nanocarriers for controlled pesticide release[J]. Nanomaterials,2016,6(7):126-138.
[4] Kumar S,Bhanjana G,Sharma A,et al. Synthesis,characterization and on field evaluation of pesticide loaded sodium alginate nanoparticles[J]. Carbohydrate Polymers,2014,101:1061-1067.
[5] Zhang W,He S,Liu Y,et al. Preparation and characterization of novel functionalized prochloraz microcapsules using silica-alginate-elements as controlled release carrier materials[J]. ACS Applied Materials&Interfaces,2014,6(14):11783-11790.
[6] Chen F,Hong H,Shi S,et al. Tumor targeted drug delivery with hollow mesoporous silica nanoparticles[J]. Journal of Nuclear Medicine,2014,55:547.
[7] Chen Y,Ai K,Liu J,et al. Multifunctional envelope-type mesoporous silica nanoparticles for p H-responsive drug delivery and magnetic resonance imaging[J]. Biomaterials,2015,60:111-120.
[8] Teng Z,Su X,Zheng Y,et al. Mesoporous silica hollow spheres with ordered radial mesochannels by a spontaneous self-transformation approach[J]. Chemistry of Materials,2012,25(1):98-105.
[9]刘群,卢芳,曾勇.紫外分光光度法测定阿维菌素预混剂的含量[J].甘肃畜牧兽医,2002,32(1):19-20.
[10] An W,Fu J,Su J,et al. Mesoporous hollow nanospheres consisting of carbon coated silica nanoparticles for robust lithium-ion battery anodes[J]. Journal of Power Sources,2017,345:227-236.
[11]陈和生,孙振亚,邵景昌.八种不同来源二氧化硅的红外光谱特征研究[J].硅酸盐通报,2011,30(4):934-937.
[12] Sheng W,Li W,Zhang G,et al. Study on the UV-shielding and controlled-release properties of a polydopamine coating for avermectin[J]. New Journal of Chemistry,2015,39(4):2752-2757.