Expression of LC3, LAMP2, KEAP1 and NRF2 in Salivary Adenoid Cystic Carcinoma

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• 作者：Cong-Fa Huang ; Wei-Wei Deng ; Lu Zhang ; Wen-Feng Zhang…
• 关键词：LC3 ; LAMP2 ; KEAP1 ; NRF2 ; Salivary adenoid cystic carcinoma
• 刊名：Pathology & Oncology Research
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：22
• 期：1
• 页码：109-114
• 全文大小：3,895 KB
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• 作者单位：Cong-Fa Huang (1)
  Wei-Wei Deng (1)
  Lu Zhang (1)
  Wen-Feng Zhang (1) (2)
  Zhi-Jun Sun (1) (2)
  
  1. The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, 37 Luoyu Road, Wuhan, 430079, People鈥檚 Republic of China
  2. Department of Oral Maxillofacial-Head Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan, China
  
• 刊物主题：Cancer Research; Oncology; Pathology; Immunology; Biomedicine general;
• 出版者：Springer Netherlands
• ISSN：1532-2807

文摘

Salivary Adenoid Cystic Carcinoma (SACC) is a tumor characterized by inevitable local progression and terminal hematogenous metastasis. This study aimed to investigate the expression of LC3, LAMP2, KEAP1 and NRF2 in SACC. Human salivary gland tissue microarray which contains 74 SACC, 12 pleomorphic adenoma and 18 normal salivary gland specimens. High expression of LC3, LAMP2, KEAP1 and NRF2 were found in SACC patients, and LC3, LAMP2, KEAP1 and NRF2 expression were significantly higher in SACC than as compared with pleomorphic adenoma and (or) normal salivary gland. The expression of NRF2 was correlated with pathological type of human SACC (P < 0.05). Moreover, the high-expression of KEAP1 had significant correlations with LC3 (P < 0.001, R = 0.3195), and LAMP2 (P < 0.001, R = 0.3346) and NRF2 (P < 0.05, R = 0.2246) by using the Pearson correlation coefficient test. Our findings demonstrated that up-regulation of LC3, LAMP2, KEAP1 and NRF2 were associated with carcinogenesis and progression of SACC patients, suggesting that they may be useful molecular targets in salivary adenoid cystic carcinoma. Keywords LC3 LAMP2 KEAP1 NRF2 Salivary adenoid cystic carcinoma