Diastereo- and Enantioselective Propargylation of Benzofuranones Catalyzed by Pybox-Copper Complex

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• 作者：Long Zhao ; Guanxin Huang ; Beibei Guo ; Lijun Xu ; Jie Chen ; Weiguo Cao ; Gang Zhao ; Xiaoyu Wu
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：November 7, 2014
• 年：2014
• 卷：16
• 期：21
• 页码：5584-5587
• 全文大小：374K
• ISSN：1523-7052

文摘

Diastereo- and enantioselective preparation of 2,2-disubstituted benzofuran-3(2H)-one has been realized by a pybox-copper catalyzed reaction between 2-substituted benzofuran-3(2H)-one and propargyl acetate. The utility of this method was demonstrated by further transformation of the terminal alkyne into a methyl ketone without loss of enantiomeric purity.