Ceftibuten: Development of a Commercial Process Based on Cephalosporin C. Part IV. Pilot-Plant Scale Electrochemical Reduction of 3-Acetoxymethyl-7(R)-glutaroylaminoceph-3-em-4-carboxylic Acid
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- 作者：Dennis Chai ; David Genders ; Norman Weinberg ; Guillermo Zappi ; Ermanno Bernasconi ; Junning Lee ; Jacopo Roletto ; Loris Sogli ; Derek Walker ; Charles R. Martin ; Vinod Menon ; Piotr Zelenay ; and Haiyan Zhan
- 刊名：Organic Process Research & Development
- 出版年：2002
- 出版时间：March 2002
- 年：2002
- 卷：6
- 期：2
- 页码：178 - 183
- 全文大小：70K
- 年卷期：v.6,no.2(March 2002)
- ISSN：1520-586X
文摘
This contribution describes the operation of a pilot plant forthe production of 3-exomethylene-7(R)-glutaroylaminocepham-4-carboxylic acid 1(S)-oxide (4a) by the electrochemical reduction of 3-acetoxymethyl-7(R)-glutaroylaminoceph-3-em-4-carboxylic acid 1(S)-oxide (3a). This conversion is a key step in anew process for the production of Ceftibuten (1). The scale-upof the electrochemical reduction was demonstrated using acommercial flow-cell. The use of a novel type of extended-areatin cathode, which had been shown on a laboratory scale toproduce significant improvements in the process, was successfully implemented in an ICI FM21-SP commercial-scale electrochemical reactor.