Silymarin exerts antifungal effects via membrane-targeted mode of action by increasing permeability and inducing oxidative stress

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• 作者：Dae Gyu Yun ; Dong Gun Lee ; ^{dglee222@knu.ac.kr}
• 关键词：MIC ; minimal inhibitory concentration ; PBS ; phosphate-buffered saline ; LUV ; large unilamellar vesicles ; PC ; phosphatidylcholine ; PE ; phosphatidylethanolamine ; PI ; phosphatidylinositol ; FD ; fluorescein isothiocyanate-labeled dextran ; ROS ; reactive oxygen species ; H2DCFDA ; 2&prime ; 7&prime ; -dichlorodihydrofluorescein diacetate ; MDA ; malondialdehyde ; TBA ; thiobarbituric acid ; DiBAC4(3) ; bis-(1 ; 3-dibutylbarbituric acid) trimethineoxonol ; DPH ; 1 ; 6-diphenyl-1 ; 3 ; 5-hexatriene
• 刊名：Biochimica et Biophysica Acta (BBA) - Biomembranes
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1859
• 期：3
• 页码：467-474
• 全文大小：948 K
• 卷排序：1859

文摘

Silymarin exerts antifungal effects against pathogenic fungi. Silymarin increases membrane permeability by disturbing fungal membrane structure. Silymarin promoted intracellular ROS generation, which leads to peroxidation of membrane lipids. Silymarin has membrane-targeted mechanism against C. albicans.