TAK1 knockdown enhances lipopolysaccharide-induced secretion of proinflammatory cytokines in myeloid cells via unleashing MEKK3 activity

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• 作者：Kun Li^a ; ^b ; Meichen Wang^c ; Yaping Hu^a ; Na Xu^a ; Qin Yu^d ; Qinfu Wang^a ; ^{qinfuwang@126.com}
• 关键词：TGF-β activating protein kinase 1 (TAK1) ; Lipopolysaccharide (LPS) ; Toll-like receptor 4 (TLR4) ; Mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 3 (MEKK3) ; Myeloid cell
• 刊名：Cellular Immunology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：310
• 期：Complete
• 页码：193-198
• 全文大小：635 K
• 卷排序：310

文摘

Knockdown of TAK1 enhanced the secretion of IL-1β and TNFα induced by LPS. LPS-activated TAK1 negatively regulates MEKK3. MEKK3 induced NF-κB activation. TAK1 negatively regulates cytokine secretion through inhibition of MEKK3.