Lack of TAK1 in dendritic cells inhibits the contact hypersensitivity response induced by trichloroethylene in local lymph node assay
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- 作者：Pan Yao ; Chu Hongqian ; Meng Qinghe ; Shang Lanqin ; Jiang Jianjun ; Yang Xiaohua ; Wei Xuetao ; Hao Weidong ; whao@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：TCE ; trichloroethylene ; CHS ; contact hypersensitivity ; TAK1 ; transforming growth factor-β activated kinase-1 ; DC ; dendritic cell ; LLNA ; local lymph node assay ; ACD ; allergic contact dermatitis ; DNFB ; 2 ; 4-dinirofluorobenzene
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：307
- 期：Complete
- 页码：72-80
- 全文大小：1520 K
文摘
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Lack of TAK1 in DC caused an abolished TCE-induced CHS response.
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TAK1 in DCs was essential to maintain the homeostasis of T cells in TCE-induced CHS.
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Intact TAK1 in DCs was critical to promote T-cell priming in TCE-induced CHS.
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DC-specific TAK1 deficiency abolished the TCE-mediated phosphorylation of Jnk.