Tetrandrine regulates hepatic stellate cell activation via TAK1 and NF-κB signaling
详细信息 查看全文
- 作者：Xia Lia ; 1 ; Quan Jina ; 1 ; Yan-Ling Wua ; Peng Sunb ; Shuang Jianga ; Yu Zhanga ; De-Quan Zhanga ; Yu-Jing Zhanga ; Li-Hua Liana ; lihualian@ymail.com" class="auth_mail" title="E-mail the corresponding author ; Ji-Xing Nana ; jxnan@ybu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：α-SMA ; α-smooth muscle actin ; ECM ; extracellular matrix ; ERK ; extracellular signal-regulated kinases ; FADD ; Fas-associated death domain protein ; HSC ; hepatic stellate cell ; JNK ; c-Jun N-terminal kinase ; MAPK ; mitogen-activated protein kinases ; NF-κB ; nuclear factor-κB ; TNF-α ; tumor necrosis factor-α ; TAK1 ; TGF-β&ndash ; activated kinase-1 ; TRADD ; TNFR-1-associated death domain
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：36
- 期：Complete
- 页码：263-270
- 全文大小：1490 K
文摘
- •
Low concentrations of tetrandrine inhibited TNF-α-stimulated TAK1 and NF-κB activation in hepatic stellate cells (HSC).
- •
At higher concentrations, tetrandrine triggered HSC apoptosis via TAK1 and NF-κB activation.
- •
At even higher concentrations, tetrandrine was cytotoxic to HSCs and hepatocytes.
- •
Anti-fibrogenic effects of tetrandrine were concentration dependent.