Phosphoinositide-dependent kinase-1 inhibits TRAF6 ubiquitination by interrupting the formation of TAK1-TAB2 complex in TLR4 signaling
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- 作者：Gyuyoung Moona ; 1 ; Juhong Kima ; 1 ; Yoon Mina ; 1 ; Sae Mi Wia ; Jae-Hyuck Shimb ; Eunyoung Chunc ; d ; Ki-Young Leea ; thylee@skku.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：PDK1 ; Phosphoinositide-dependent protein kinase 1 ; TLR ; Toll-like receptor ; TRAF6 ; tumor necrosis factor (TNF) receptor-associated factor 6 ; TAK1 ; transforming growth factor beta-activated kinase 1 ; TAB2 ; TAK1 binding protein 2 ; NF-κB ; nuclear factor kappa B ; PAMPs ; pathogen-associated molecular patterns
- 刊名：Cellular Signalling
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：27
- 期：12
- 页码：2524-2533
- 全文大小：1624 K
文摘
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PDK1 negatively influences TLR4 signaling.
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PDK1-knockdown enhances NF-κB activation induced by TLR4.
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PDK1 interacts with TAK1 and inhibits TAK1 activation.
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PDK1 inhibits TRAF6 ubiquitination by interrupting TAK1–TAB2 complex.