Inhibition of 11β-hydroxysteroid dehydrogenase type 1 by plant extracts used as traditional antidiabetic medicines
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- 作者：Christel Gumy ; Carmen Thurnbichler ; Evelyne M. Aubry ; Zoltan Balazs ; Petra Pfisterer ; Lisa Baumgartner ; Hermann Stuppner ; Alex Odermatt ; Judith M. Rollinger
- 关键词：Diabetes ; Glucocorticoid receptor ; Metabolic syndrome ; Eriobotrya japonica ; Coffea arabica
- 刊名：Fitoterapia
- 出版年：2009
- 出版时间：April 2009
- 年：2009
- 卷：80
- 期：3
- 页码：200-205
- 全文大小：309 K
文摘
Elevated glucocorticoids are a key risk factor for metabolic diseases, and the glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) represents a promising therapeutic target. We measured the potential of six traditional antidiabetic medicinal plants extracts to inhibit 11β-HSD1 activity and glucocorticoid receptor (GR) activation in transfected HEK-293 cells. Leave extracts of Eriobotrya japonica preferentially inhibited 11β-HSD1 over 11β-HSD2. Extracts of roasted but not native coffee beans preferentially inhibited 11β-HSD1 over 11β-HSD2, emphasizing the importance of sample preparation. Thus, natural compounds inhibiting 11β-HSD1 may contribute to the antidiabetic effect of the investigated plant extracts.