Dysregulated fatty acid metabolism in coronary ectasia: An extended lipidomic analysis

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• 作者：Usama Boles^a ; ^b ; Rui Climaco Pinto^c ; ^d ; Santosh David^b ; Abdullah S Abdullah^b ; Michael Y Henein^a ; ^{michael.henein@medicin.umu.se}
• 关键词：Coronary artery ectasia ; Lipidomic analysis ; Phosphatidylcholine ; Sphyngeomyeline ; Atherosclerosis
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：228
• 期：Complete
• 页码：303-308
• 全文大小：744 K
• 卷排序：228

文摘

Coronary artery ectasia (CAE) is not an uncommon clinical condition, which could be associated with adverse outcome. The exact pathophysiology of the disease is poorly understood and is commonly interpreted as a variant of atherosclerosis. In this study, we sought to undertake lipidomic profiling of a group of CAE patients in an attempt to achieve better understanding of its disturbed metabolism.MethodsUntargeted lipid profiling and complementary modelling strategies were employed to compare serum samples from 16 patients with CAE (mean age 63.5 ± 10.1 years, 6 female) and 26 controls with normal smooth coronary arteries (mean age 59.2 ± 6.6 years and 7 female). Sample preparation, LC-MS analysis and metabolite identification were performed at the Swedish Metabolomics Centre, Umeå, Sweden.ResultsPhosphatidylcholine levels were significantly distorted in the CAE patients (p = 0.001–0.04). Specifically, 16-carbon fatty acyl chain phosphatidylcholines (PC) were detected in lower levels. Similarly, 11 meioties of Sphyngomyelin (SM) species were detected at lower concentrations (p = 0.000001–0.01) in the same group. However, only three metabolites were significantly higher in the pure CAE subgroup (6 patients) when compared with the 10 mixed CAE patients (two meioties of SM species and one of PC). Atherosclerosis risk factors were not different between groups.ConclusionThis is the first lipid profiling study reported in coronary artery ectasia. While the lower concentration and dysregulation of sphyngomyelin suggests an evidence for premature apoptosis, that of phosphatidylcholines suggests perturbed fatty acid elongation/desaturation, thus may be indicative of non-atherogenic process in CAE.