Deficiency of glycerol-3-phosphate acyltransferase 1 decreases triacylglycerol storage and induces fatty acid oxidation in insect fat body

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• 作者：Michele Alves-Bezerra^a ; ^b ; Isabela B. Ramos^a ; Iron F. De Paula^a ; Clarissa M. Maya-Monteiro^c ; Eric L. Klett^b ; ^d ; Rosalind A. Coleman^b ; Katia C. Gondim^a ; ^{katia@bioqmed.ufrj.br}
• 关键词：ACBP1 ; acyl-CoA-binding protein 1 ; ACSL1 ; acyl-CoA synthetase 1 ; BAT ; brown adipose tissue ; CPT1 ; carnitine palmitoyltransferase 1 ; DAG ; diacylglycerol ; ER ; endoplasmic reticulum ; G3P ; glycerol-3-phosphate ; GPAT ; glycerol-3-phosphate acyltransferase ; LD ; lipid droplet ; LPA ; lysophosphatidic acid ; NEM ; N-ethylmaleimide ; PA ; phosphatidic acid ; PL ; phospholipid ; TAG ; triacylglycerol
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1862
• 期：3
• 页码：324-336
• 全文大小：1950 K
• 卷排序：1862

文摘

Two GPAT genes were cloned and shown to be independently regulated. GPAT activities varied between organs. GPAT1 was required for TAG accumulation in the midgut and fat body. GPAT1 knockdown induced the oxidation of fatty acids.