Autophagy in MCF-7 cancer cells induced by copper complexes
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- 作者：Katarí ; na Koňariková ; a ; Georgios A. Perdikarisa ; Helena Gbelcová ; b ; Lucia Andrezá ; lová ; a ; Martin &Scaron ; vé ; dac ; Tomá ; &scaron ; Rumlc ; Lucia Laubertová ; a ; Soňa Režná ; ková ; b ; Ingrid Žitňanová ; a ; ingrid.zitnanova@fmed.uniba.sk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Schiff base copper complexes ; Autophagy ; Cell death ; Cancer cell lines
- 刊名：Pharmacological Reports
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：68
- 期：6
- 页码：1221-1224
- 全文大小：514 K
文摘
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IC50 values of Cu(II) complexes tested on MCF-7 cancer cells increased in a time- dependent manner.
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Noncancer cells were not sensitive to Cu(II) complexes.
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In MCF-7 cells Cu(II) complexes induced condensation and asymmetric conformational changes in actin filaments.
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Cu(II) complexes did not induce apoptosis in MCF-7.
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Cu(II) complexes induced autophagy in MCF-7.