Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit
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- 作者：Thomas Bertero1 ; 11 ; Katherine A. Cottrill1 ; Yu Lu1 ; Christina M. Haeger2 ; Paul Dieffenbach2 ; Sofia Annis1 ; Andrew Hale1 ; Balkrishen Bhat3 ; 12 ; Vivek Kaimal3 ; Ying-Yi Zhang1 ; Brian B. Graham4 ; Rahul Kumar4 ; Rajan Saggar5 ; Rajeev Saggar6 ; W. Dean Wallace5 ; David J. Ross5 ; Stephen M. Black7 ; Sohrab Fratz8 ; Jeffrey R. Fineman9 ; Sara O. Vargas10 ; Kathleen J. Haley2 ; Aaron B. Waxman2 ; B. Nelson Chau3 ; 12 ; Laura E. Fredenburgh2 ; Stephen Y. Chan1 ; 13 ; chansy@pitt.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：3 November 2015
- 年：2015
- 卷：13
- 期：5
- 页码：1016-1032
- 全文大小：7506 K
文摘
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Matrix remodeling induces YAP/TAZ-miR-130/301 early in pulmonary hypertension (PH)
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YAP/TAZ-miR-130/301 promotes matrix remodeling via a mechanoactive feedback loop
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Such matrix remodeling drives pulmonary vascular activation and cellular crosstalk
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Pharmacologic modulation of this circuit ameliorates matrix remodeling and PH