The conserved regulation of mitochondrial uncoupling proteins: From unicellular eukaryotes to mammals
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- 作者：Andrzej M. Woyda-Ploszczyca ; Wieslawa Jarmuszkiewicz ; wiesiaj@amu.edu.pl
- 关键词：AcUCP ; Acanthamoeba castellanii UCP ; ANT ; adenine nucleotide translocase ; BAT ; brown adipose tissue ; CATR ; carboxyatractyloside ; FFA ; free fatty acid ; HNE ; 4-hydroxy-2-nonenal ; MACP family ; mitochondrial anion carrier protein family ; mΔΨ ; mitochondrial membrane potential ; mNDPK ; mitochondrial nucleotide diphosphate kinase ; OXPHOS ; oxidative phosphorylation ; PN ; purine nucleotide ; ROS ; reactive oxygen species ; RA ; all trans-retinoic acid ; RAL ; all trans-retinal ; StUCP ; Solanum tuberosum UCP ; Q ; c
- 刊名：Biochimica et Biophysica Acta (BBA) - Bioenergetics
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：1858
- 期：1
- 页码：21-33
- 全文大小：917 K
- 卷排序：1858
文摘
Ligand-dependent regulation of UCPs is conserved among eukaryotes. GTP, rather than GDP, should be employed as a diagnostic inhibitor of UCP. UCP activation involves rapid and late responses.