Nicotine versus 6-hydroxy-l-nicotine against chlorisondamine induced memory impairment and oxidative stress in the rat hippocampus

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• 作者：Lucian Hritcu ; ^{hritcu@uaic.ro} ; Radu Ionita ; Diana Elena Motei ; Cornelia Babii ; Marius Stefan ; Marius Mihasan ; ^{marius.mihasan@uaic.ro}
• 关键词：Arthrobacter nicotinovorans ; Nicotine ; 6-Hydroxy-l-nicotine ; Chlorisondamine ; Memory ; Oxidative stress
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：86
• 期：Complete
• 页码：102-108
• 全文大小：1221 K
• 卷排序：86

文摘

6-Hydroxy-l-nicotine (6HLN), a nicotine derivative from nicotine degradation by Arthrobacter nicotinovorans pAO1 strain was found to improve behavioral deficits and to reverse oxidative stress in the rat hippocampus. Rats were given CHL (10 mg/kg, i.p.) were used as an Alzheimer’s disease-like model. The nicotine (0.3 mg/kg) and 6HLN (0.3 mg/kg) were administered alone or in combination in the CHL-treated rats. Memory-related behaviors were evaluated using Y-maze and radial arm-maze tests. The antioxidant enzymes activity and the levels of the biomarkers of oxidative stress were measured in the hippocampus. Statistical analyses were performed using two-way ANOVA and Tukey’s post hoc test. F values for which p < 0.05 were regarded as statistically significant. CHL-caused memory deficits and oxidative stress enhancing were observed. Both nicotine and 6HLN administration attenuated the cognitive deficits and recovered the antioxidant capacity in the rat hippocampus of the CHL rat model.Our results suggest that 6HLN versus nicotine confers anti-amnesic properties in the CHL-induced a rat model of memory impairment via reversing cholinergic function and decreasing brain oxidative stress, suggesting the use of this compound as an alternative agent in AD treatment.