EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage

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• 作者：Mi-Hwi Kim^a ; ^b ; Eung-Hwi Kim^a ; ^b ; Hye Seung Jung^c ; Dongki Yang^d ; Eun-Young Park^e ; ^{parkey@mokpo.ac.kr} ; Hee-Sook Jun^a ; ^b ; ^f ; ^{hsjun@gachon.ac.kr}
• 关键词：Oxidative stress ; Exendin-4 ; Nrf2 ; Beta cell ; INS-1 cell ; Type 2 diabetes
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：315
• 期：Complete
• 页码：60-69
• 全文大小：1100 K
• 卷排序：315

文摘

EX4 protects against oxidative stress-induced pancreatic beta cell dysfunction. EX4 increases antioxidant gene expression. Antioxidative effect of EX4 is mediated by Nrf2. EX4 increases Nrf2 level by stabilizing Nrf2 protein. EX4 stabilizes Nrf2 by activation of PKCδ.