Structural characterization of lyotropic liquid crystals containing a dendrimer for solubilization and release of gallic acid

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• 作者：Liron Bitan-Cherbakovsky ; Abraham Aserin ; Nissim Garti
• 关键词：Hexagonal mesophases ; Lamellar mesophases ; Cubic mesophases ; Drug release ; Vitamin E
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：1 December, 2013
• 年：2013
• 卷：112
• 期：Complete
• 页码：87-95
• 全文大小：2977 K

文摘

The role of 2nd generation polypropyleneimine (PPIG2) dendrimer in controlling the release of gallic acid (GA) as a model drug from lyotropic liquid crystal was explored. GA (0.2 wt%) was solubilized in three types of mesophases: lamellar (L_伪), cubic (space group of Ia3d, Q^G), and reverse hexagonal (H_II), composed of GMO and water (and d-伪-tocopherol, or tricaprylin in the case of H_II mesophases).

Small angle X-ray scattering (SAXS) and attenuated total reflectance Fourier transform infrared (ATR-FTIR) along with UV spectrophotometry were utilized to elucidate the structure modifications and release resulting from the cosolubilization of GA and PPIG2.

Solubilization of PPIG2 into L_伪 and Q^G phases caused transformation of both structures to H_II. The diffusion of GA out of the mesophases was found to be dependent on water content and PPIG2 concentration. Rapid release from L_伪 + PPIG2 and Q^G + PPIG2 mesophases was recorded. The release from both H_II mixtures (with d-伪-tocopherol and tricaprylin) was shown to be dependent on the type of oil.

Release studies conducted for 72 h showed that GA release can be modulated and sustained by the presence of PPIG2, supposedly due to the electrostatic interactions between the dendrimer and the drug molecule.