- 作者：Dafr Allah Benajah ; Mounia Lahbabi ; Samia Alaoui ; Karima El Rhazi ; Mohammed El Abkari ; Chakib Nejjari ; Afaf Amarti ; Bahia Bennani ; Mustapha Mahmoud ; Sidi Adil Ibrahimi
- 刊名：Clinics and Research in Hepatology and Gastroenterology
- 出版年：November, 2013
- 年：2013
- 卷：37
- 期：5
- 页码：519-526
- 全文大小：330 K
Summary
Introduction
In developed countries, reinfection after successful eradication of Helicobacter pylori appears unusual. High prevalences of H.聽pylori in developing countries may result in high reinfection rates. In Morocco, published studies regarding the prevalence of H.聽pylori are limited, and to our knowledge, there are no data regarding the reinfection rate of H.聽pylori after successful treatment.Aim
The aim of this study was to determine the prevalence of H.聽pylori in our area, and the reinfection rate at 6 months and 1 year of follow-up after successful eradication.
Methods
Consecutive patients with investigated ulcer or non-ulcer dyspepsia were prospectively enrolled in the Hassan II University Hospital of Fez. Patients with H.聽pylori infection were treated with a 1-week triple therapy or 10 day sequential therapy. Those tested urea breath test negative after 3 months of treatment were followed prospectively with repeated urea breath test at 6 months and 1 year. H.聽pylori status at endoscopic examination was determined by rapid urease test, histology, and culture.
Results
Four hundred and twenty-nine patients were enrolled in the study, among them 324 patients (75.5%) presented with H.聽pylori infection. Two hundred and fifty-six (83.3%) patients had successfully eradicated H.聽pylori following treatment, among them, two patients (0.8%) were reinfected with H.聽pylori over 12 months. The rate of reinfection was 0.42% in the first 6 months and of 0.45% in the first year of the study.
Conclusion
The results of the present study demonstrate that firstly, prevalence of H.聽pylori is high (75.5%) in our area, secondly as in developed countries, there is a low (0.8%) but continuous risk of H.聽pylori infection in adulthood. A different approach for follow-up after H.聽pylori eradication is probably needed in patients of developing countries, since reinfection prevalence is different between countries.