- 作者：Mounia Lahbabi ; Samia Alaoui ; Karima El Rhazi ; Mohammed El Abkari ; Chakib Nejjari ; Afaf Amarti ; Bahia Bennani ; Mustapha Mahmoud ; Adil Ibrahimi ; Dafr Allah Benajah
- 刊名：Clinics and Research in Hepatology and Gastroenterology
- 出版年：2013
- 出版时间：September, 2013
- 年：2013
- 卷：37
- 期：4
- 页码：416-421
- 全文大小：336 K
Summary
Objective
The aim of this study was to assess and compare the efficacy and safety of sequential treatment with standard triple therapies in a located population in Morocco.Methods
Consecutive H.?pylori-positive patients with endoscopy-proven ulcer or non ulcer dyspepsia were prospectively randomized in the trial into one of three groups: AM and AC group were administered a tri-therapy for 7 days including PPI + amoxicillin + metronidazole (AM group)/clarithromycin (AC group) and SQ group was administered a sequential regimen consisting of PPI + amoxicillin for 5 days followed by PPI + clarithromycin + metronidazole for the remaining 5 days. Eradication was confirmed by 13C-urea breath test 3 months after the end of the treatment.
Results
Groups AM, AC and SQ included respectively 104, 115 and 104 patients. They were comparable in terms of age, sex, clinical and endoscopic presentation. The rate of H.?pylori eradication with sequential therapy was found at 94.2 % (n = 98) in ITT and 96 % (n = 98) in PP. It was higher than those found in the AM group: 70 % (n = 73) in ITT and 70.8 % (n = 73) in PP and the AC group: 78.2 % (n = 90) in ITT and 79.6 % (n = 90) in PP (0.001). The prevalence of side effects following the sequential treatment was 9.6 % (n = 10) versus 22 % (n = 22) and 27.8 % (n = 32) in the AM and AC groups, respectively, (P = 0.006).
Conclusions
Sequential treatment was better tolerated and achieved a significantly higher eradication rate of H.?pylori compared with standard triple therapies in this population.