Highly sensitive LC-MS/MS methods for the determination of seven human CYP450 activities using small oral doses of probe-drugs in human

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• 作者：Alexia Grangeon^a ; ^b ; ^{alexia.grangeon@umontreal.ca} ; Sophie Gravel^a ; ^b ; ^{sophie.gravel.3@umontreal.ca} ; Fleur Gaudette^b ; ^{fleur.gaudette.chum@ssss.gouv.qc.ca} ; Jacques Turgeon^a ; ^b ; ^{jacques.turgeon@umontreal.ca} ; Veronique Michaud^a ; ^b ; ^{v.michaud@umontreal.ca}
• 关键词：LC&ndash ; MS/MS ; CYP450 probe-drug cocktail ; Drug metabolism ; Drug-drug interactions ; Phenotyping
• 刊名：Journal of Chromatography B
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：1040
• 期：Complete
• 页码：144-158
• 全文大小：1846 K
• 卷排序：1040

文摘

Development and validation of highly sensitive and specific LC–MS/MS assays. Low oral doses of selective probe drugs used to phenotype major CYP450 activities. Determination of inter-individual variabilities in major CYP450 activities. Evaluation of drug metabolism CYP450 activities in vulnerable patients.