Enantiomeric separation of antimalarial drugs by capillary electrophoresis using neutral and negatively charged cyclodextrins
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- 作者：Krisztina Né ; meth ; Gá ; bor Tá ; rká ; nyi ; Erzsé ; bet Varga ; Tí ; mea Imre ; Ré ; ka Mizsei ; Ró ; bert Ivá ; nyi ; Jú ; lia Visy ; Julianna Szemá ; n ; Lá ; szló ; Jicsinszk
- 关键词：Antimalarial drugs ; Enantioselective analysis ; Drug impurity ; Cyclodextrin modified capillary zone electrophoresis
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2011
- 出版时间：20 February 2011
- 年：2011
- 卷：54
- 期：3
- 页码：475-481
- 全文大小：292 K
文摘
Capillary electrophoresis (CE) methods for chiral resolution of five antimalarial drugs (primaquine, tafenoquine, mefloquine, chloroquine and quinacrine) were developed by using a wide selection of neutral and anionic cyclodextrin (CD) derivatives. The use of sulfobutyl-β-CD and carboxymethyl-β-CD (CMBCD) resulted in good resolution of quinacrine and tafenoquine, respectively. New results are presented for resolutions of chloroquine and mefloquine. Application of carboxyalkyl- and sulfobutyl-CD derivatives provided improved resolution for primaquine. The impurity in primaquine sample detected by CE was identified as quinocide by MS and NMR. CMBCD provided not only the best separation of primaquine from quinocide but also the simultaneous complete resolution of both compounds.