Nitrosylation of imidazo[1,2-a]pyridines in metal free system

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• 作者：Xin-Qi Hao^a ; Wen-Bo Liu^a ; Xiao-Jing Shen^a ; Wei Wang^b ; Zhi-Kun Liang^a ; Xinju Zhu^a ; ^{zhuxinju@zzu.edu.cn} ; Mao-Ping Song^a ; ^{mpsong@zzu.edu.cn}
• 关键词：Nitrosylation ; Imidazo[1 ; 2-a]pyridines ; tert-Butyl nitrite (TBN) ; Near quantitative yields
• 刊名：Journal of Saudi Chemical Society
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：21
• 期：1
• 页码：91-94
• 全文大小：584 K
• 卷排序：21

文摘

An efficient nitrosylation of imidazo[1,2-a]pyridines has been developed using tert-Butyl nitrite (TBN) as the NO resource. The nitrosylation protocol demonstrates broad compatibilities, with various functional groups such as halogen, Me, OMe, COOMe et al. well tolerated. Near quantitative yields could be obtained within the imidazo[1,2-a]pyridine scaffold under the optimized conditions.