A role for Toll-like receptor 4 in the host response to the lung infection of Yersinia pseudotuberculosis in mice
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- 作者：Jin-A Choia ; Yu-Jin Jeonga ; Jae-Eun Kima ; Min-Jung Kangb ; Jee-Cheon Kimc ; Sang-Muk Oha ; Kyung-Bok Leea ; Dong-Hyun Kimd ; Dong-Jae Kime ; Kimdj77@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Jong-Hwan Parkb ; jonpark@jnu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Yersinia pseudotuberculosis ; Lung infection ; Systemic dissemination ; Toll-like receptor 4
- 刊名：Comparative Immunology, Microbiology and Infectious Diseases
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：44
- 期：Complete
- 页码：54-60
- 全文大小：2561 K
文摘
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Lung infection with Yptb strain IP2777 induces systemic infection in mice.
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TLR4 protects mice from lethality induced by lung infection with Yptb.
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TLR deficiency leads to rapid spreading of bacteria into systemic organs.
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More severe pathology was observed in the liver and spleen of TLR4-deficient mice.