White Matter Volume Predicts Language Development in Congenital Heart Disease

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• 作者：Caitlin K. Rollins ; MD¹ ; ² ; Lisa A. Asaro ; MS³ ; Alireza Akhondi-Asl ; PhD⁴ ; ⁵ ; Barry D. Kussman ; MBBCh⁵ ; ⁶ ; Michael J. Rivkin ; MD¹ ; ² ; ⁷ ; ⁸ ; David C. Bellinger ; PhD ; MSc¹ ; ² ; ⁸ ; Simon K. Warfield ; PhD⁴ ; ⁷ ; David Wypij ; PhD³ ; ⁹ ; ¹⁰ ; Jane W. Newburger ; MD ; MPH³ ; ⁹ ; Janet S. Soul ; MD ; CM¹ ; ² ; ^{janet.soul@childrens.harvard.edu}
• 关键词：brain ; MRI ; neurodevelopment ; language ; infant
• 刊名：The Journal of Pediatrics
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：181
• 期：Complete
• 页码：42-48.e2
• 全文大小：349 K
• 卷排序：181

文摘

To determine whether brain volume is reduced at 1 year of age and whether these volumes are associated with neurodevelopment in biventricular congenital heart disease (CHD) repaired in infancy.Study designInfants with biventricular CHD (n = 48) underwent brain magnetic resonance imaging (MRI) and neurodevelopmental testing with the Bayley Scales of Infant Development-II and the MacArthur-Bates Communicative Development Inventories at 1 year of age. A multitemplate based probabilistic segmentation algorithm was applied to volumetric MRI data. We compared volumes with those of 13 healthy control infants of comparable ages. In the group with CHD, we measured Spearman correlations between neurodevelopmental outcomes and the residuals from linear regression of the volumes on corrected chronological age at MRI and sex.ResultsCompared with controls, infants with CHD had reductions of 54 mL in total brain (P = .009), 40 mL in cerebral white matter (P < .001), and 1.2 mL in brainstem (P = .003) volumes. Within the group with CHD, brain volumes were not correlated with Bayley Scales of Infant Development-II scores but did correlate positively with MacArthur-Bates Communicative Development Inventory language development.ConclusionsInfants with biventricular CHD show total brain volume reductions at 1 year of age, driven by differences in cerebral white matter. White matter volume correlates with language development, but not broader developmental indices. These findings suggest that abnormalities in white matter development detected months after corrective heart surgery may contribute to language impairment.Trial registrationClinicalTrials.gov: NCT00006183.