HIV and Nonischemic Heart Disease
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- 作者：Pravin Manga ; MBBCh ; PhD ; Pravin.Manga@wits.ac.za ; Keir McCutcheon ; MBBCh ; Nqoba Tsabedze ; MBBCh ; Ahmed Vachiat ; MBBCh ; Don Zachariah ; MBBCh
- 关键词：acquired immunodeficiency syndrome ; antiretroviral agents ; HIV-associated cardiomyopathy ; HIV-associated pulmonary artery hypertension
- 刊名：Journal of the American College of Cardiology
- 出版年：2017
- 出版时间：3-10 January 2017
- 年：2017
- 卷：69
- 期：1
- 页码：83-91
- 全文大小：460 K
- 卷排序：69
文摘
Human immunodeficiency virus (HIV)-associated heart disease encompasses a broad spectrum of diseases. HIV infection may involve the pericardium, myocardium, coronary arteries, pulmonary vasculature, and valves, as well as the systemic vasculature. Access to combination antiretroviral therapy, as well as health resources, has had a significant influence on the prevalence and severity of the effects on each cardiac structure. Investigations over the recent past have improved our understanding of the epidemiology and pathophysiology of HIV-associated cardiovascular disease. This review will focus on our current understanding of pathogenesis and risk factors associated with HIV infection and heart disease, and it will discuss relevant advances in diagnosis and management of these conditions.