HIV and Ischemic Heart Disease

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• 作者：Ahmed Vachiat ; MBBCh ; Keir McCutcheon ; MBBCh ; Nqoba Tsabedze ; MBBCh ; Don Zachariah ; MBBCh ; Pravin Manga ; MBBCh ; PhD ; ^{Pravin.Manga@wits.ac.za}
• 关键词：acquired immunodeficiency syndrome ; antiretroviral agents ; atherosclerosis ; coronary heart disease ; drug interactions ; myocardial infarction
• 刊名：Journal of the American College of Cardiology
• 出版年：2017
• 出版时间：3-10 January 2017
• 年：2017
• 卷：69
• 期：1
• 页码：73-82
• 全文大小：630 K
• 卷排序：69

文摘

The association of coronary heart disease (CHD) and human immunodeficiency virus (HIV) infection has been well recognized for many years. The etiology of the increased prevalence of CHD in HIV-infected populations is the result of complex interactions among the viral infection, host factors, traditional risk factors, and therapies for HIV. As the HIV population is living longer, largely attributable to combination antiretroviral therapy, there is concern about the effect of the rising prevalence of CHD on morbidity and mortality, as well its effect on health systems around the world. This review will highlight the epidemiological evidence linking HIV infection and CHD. It will also focus on our current understanding of the pathogenesis and factors associated with HIV infection and CHD. In addition, the review will highlight modes of presentation and management strategies for mitigating risk and treatment of HIV-positive patients presenting with CHD.