Falsely elevated serum antim¨¹llerian hormone level in a context of heterophilic interference

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• 作者：Hé ; lè ; ne Cappy ; M.D.^a ; Pascal Pigny ; Ph.D.^b ; Maryse Leroy-Billiard ; M.D.^a ; Didier Dewailly ; M.D.^a ; Sophie Catteau-Jonard ; Ph.D.^a ; ^{sophie.jonard@chru-lille.fr}
• 关键词：Antimü ; llerian hormone ; heterophile antibodies ; immunoassay
• 刊名：Fertility and Sterility
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：99
• 期：6
• 页码：1729-1732
• 全文大小：108 K

文摘

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Objective

To describe a case of falsely elevated serum antim¨¹llerian hormone (AMH) level in an infertile 37-year-old woman with rheumatoid arthritis.

Design

Case report.

Setting

Lille University IVF center.

Patient(s)

A 37-year-old woman with rheumatoid arthritis demonstrating a high serum AMH level (74.5 ng/mL) and a low antral follicle count.

Intervention(s)

Assay with a Heterophilic Blocking Tube (HBT) to avoid heterophilic interference.

Main Outcome Measure(s)

Serum AMH level, ultrasound antral follicle count, hormonal assays on the 4th day of a spontaneous cycle.

Result(s)

The results of the infertility workup were as follows: serum AMH: 74.5 ng/mL (15-fold the upper limit of normal) (immunoassay: Immunotech); LH: 3.2 IU/L; FSH: 4.5 IU/L; E₂: 27 pg/mL; PRL: 10 ng/mL. The antral follicle count (follicles from 2 to 9 mm) at ultrasound was 7 for both ovaries. Because there were discrepancies between the serum AMH level and the results of the infertility workup using the bioassays, we suspected a case of falsely elevated AMH level due to heterophilic interference. An HBT tube revealed a serum AMH level of 0.63 ng/mL.

Conclusion(s)

This case illustrates, for the first time, the possibility of a falsely high serum AMH level due to heterophilic interference.