Association of HLA-G*01:01:02:01/G*01:04:01 polymorphism with gastric adenocarcinoma

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• 作者：Samaneh Khorrami^a ; Roghayeh Rahimi^b ; Hemn Mohammadpour^b ; Salahadin Bahrami^c ; Fatemeh Yari^d ; Hossein Poustchi^a ; Reza Malekzadeh^a ; ^{malek@tums.ac.ir" class="auth_mail" title="E-mail the corresponding author}
• 关键词：HLA-G ; Polymorphism ; Gastric adenocarcinoma ; Iranian population
• 刊名：Human Immunology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：77
• 期：2
• 页码：153-157
• 全文大小：453 K

文摘

Human leukocyte antigen-G (HLA-G) plays an important role in tumor cell escape from immune surveillance and HLA-G polymorphisms might service as a potential risk factor for clinical outcomes in GAC (gastric adenocarcinoma). We investigated the association between HLA-G polymorphisms as well as soluble HLA-G level and accordance of GAC. This case-control study included 100 GAC patients and 102 unrelated Iranian individual’s samples as control. The clinical stages ranged from I to IV. PCR-RFLP method was carried out in order to specify the genotypes of the HLA-G gene. Concentrations of sHLA-G in serum were determined with the sHLA-G-specific enzyme linked immunosorbent assay (ELISA) kit. The G*01:04:01 and G*01:01:02:01 alleles were the predominant alleles in GAC patients and healthy controls. The G*01:01:03:01 and G*01:01:08 allele distributions are significantly higher among controls comparing to cases and seem to have protective effect (P value = 0.026 and 0.007 respectively). There is a substantial differences in G*01:01:02:01/G*01:04:01 genotype frequencies between cases and controls (OR = 2.8, P value < 0.001). The G*01:01:03:01/G*01:04:01 and G*01:01:02:01/G*01:01:08 genotypes frequency are higher among controls in comparison to patients (P value = 0.028 and 0.007 respectively). The polymorphisms in HLA-G could affect GAC induction and its outcome. Also, increased sHLA-G levels in serum might be a useful biomarker for diagnosis.