Differential regulation of GluA1 expression by ketamine and memantine
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- 作者：Ke Zhanga ; Vitor Nagai Yamakia ; Zhisheng Weib ; c ; Yu Zhengb ; c ; Xiang Caia ; d ; cai001@siu.edu" class="auth_mail" title="E-mail the corresponding author ; xcai@siumed.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Major depressive disorder ; Ketamine ; Memantine ; AMPA receptor ; GluA1 Ser845
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：316
- 期：Complete
- 页码：152-159
- 全文大小：1647 K
文摘
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Memantine potentiates Schaffer collateral-CA1 excitatory synaptic transmission in hippocampal area CA1.
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Administration of memantine or ketamine enhances GluA1 S845 phosphorylation, but only ketamine elevates the expression of GluA1.
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Memantine-induced potentiation of SC-CA1 synaptic phosphorylation and GluA1 phosphorylation are not occluded by GAGA receptor blockade.
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Ketamine but not memantine enhances the phosphorylation of mTOR, in a time course parallel to the elevation of GluA1 expression.
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Neither ketamine or memantine reduces the phosphorylation of eEF2; instead, ketamine enhances eEF2 phosphorylation 30 min following administration.