HDL subpopulations containing apoA-I without apoA-II (LpA-I) in patients with angiographically proven coronary artery disease

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• 作者：Agnieszka Kuchta ; PhD^a ; ^{agakuchta@gumed.edu.pl} ; Adrian Strzelecki ; MD^b ; Agnieszka Ćwiklińska ; PhD^a ; Marcin Gruchała ; MD ; PhD^c ; Zbigniew Zdrojewski ; MD ; PhD^b ; Barbara Kortas-Stempak ; PhD^a ; Ewa Wieczorek ; MSc^a ; Anna Gliwińska ; MSc^a ; Kamil Dąbkowski ; MSc^a ; Maciej Jankowski ; MD ; PhD^a
• 关键词：Coronary artery disease ; High density lipoprotein ; Preβ1-high density lipoprotein ; Apolipoprotein A-I
• 刊名：Journal of Cardiology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：69
• 期：3
• 页码：523-528
• 全文大小：739 K
• 卷排序：69

文摘

High density lipoproteins (HDL) can be divided into two metabolically distinct fractions, one containing apolipoprotein (Apo) A-I but not ApoA-II [apolipoprotein A-I; lipoprotein (Lp) A-I] and the other containing both ApoA-I and ApoA-II (LpA-I/A-II). LpA-I fraction which, seeming to be more cardioprotective than LpA-I/A-II particles, is itself heterogeneous. Preβ1-HDL is a minor subfraction of LpA-I and the initial acceptor of cellular cholesterol in the process of reverse cholesterol transport. The aim of the study was to determine the usefulness of the determination of LpA-I fractions as indicators for the atherosclerotic process.MethodsThe study included 112 patients with angiographically-documented coronary artery disease (CAD+) and 51 patients with negative results of coronary angiography (CAD−). We evaluated LpA-I concentration in serum in HDL2 and HDL3 fractions as well as Preβ1-HDL concentration. Furthermore, we analyzed the association of the assessed parameters with the extent and severity of CAD assessed by Gensini score.ResultsCAD+ patients were characterized by a lower concentration of serum LpA-I by 19%, LpA-I in HDL2 by 26%, higher level of Preβ1-HDL by 27%, and elevated Preβ1-HDL/LpA-I values by 62%. Univariate correlation analysis indicated that serum LpA-I and HDL-cholesterol concentrations were negatively correlated with Gensini score (R = −0.279; p = 0.002, R = −0.227; p = 0.016, respectively) whereas Preβ1-HDL/LpA-I values were positively correlated with the severity of CAD (R = 0.529; p < 0.001). In multiple linear regression, after adjusting for age, gender, preexisting hypertension, diabetes, and statin therapy, only the Preβ1-HDL/LpA-I values remained an independent determinant of atherosclerosis severity (β = −0.499; p < 0.001).ConclusionsOur results show a lower level of LpA-I and higher concentration of Preβ1-HDL in the CAD+ patients compared to the CAD− group. We suggest that the distribution of LpA-I is different in CAD and the Preβ1-HDL/LpA-I ratio may have additional value in assessing anti-atherogenic potential of HDL particles and it is likely to become a clinically valuable indicator of atherosclerosis development.