Lysophosphatidic acid (LPA) signaling via LPA₄ and LPA₆ negatively regulates cell motile activities of colon cancer cells

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• 作者：Kaede Takahashi^a ; Kaori Fukushima^a ; Yuka Onishi^a ; Karin Inui^a ; Yusuke Node^a ; Nobuyuki Fukushima^b ; Kanya Honoki^c ; Toshifumi Tsujiuchi^a ; ^{ttujiuch@life.kindai.ac.jp}
• 关键词：LPA ; LPA receptor ; Cell motility ; Fluorouracil ; Colon cancer cells
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：652-657
• 全文大小：1112 K
• 卷排序：483

文摘

The cell motile activities of DLD1 and HCT116 cells were stimulated by LPA4 and LPA6 knockdown. 5-FU treatment enhanced the cell motile activity of DLD1 cells. The expressions of LPAR1, LPAR4 and LPAR6 genes were elevated in 5-FU treated cells. The cell motile activity of 5-FU treated cells was inhibited by LPA1 knockdown. LPA4 and LPA6 negatively regulates the cell motile activities of colon cancer cells as well as 5-FU treated cells.