Both genetic deletion and pharmacological blockade of lysophosphatidic acid LPA1 receptor results in increased alcohol consumption
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- 作者：Estela Castilla-Ortegaa ; 1 ; Francisco Javier Pavó ; na ; 1 ; Laura Sá ; nchez-Marí ; na ; Guillermo Estivill-Torrú ; sb ; Carmen Pedrazac ; Eduardo Blancod ; Juan Suá ; reza ; Luis Santí ; nc ; Fernando Rodrí ; guez de Fonsecaa ; antonia.serrano@ibima.eu" class="auth_mail" title="E-mail the corresponding author ; Antonia Serranoa ; fernando.rodriguez@ibima.eu" class="auth_mail" title="E-mail the corresponding author
- 关键词：LPA1 receptors ; Ethanol intake ; Preference ; LPA1-Null mice ; Ki16425
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：103
- 期：Complete
- 页码：92-103
- 全文大小：674 K
文摘
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A novel and relevant role for the LPA/LPA1 signaling is proposed.
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LPA1-null mice are a new genetic model for excessive alcohol consumption vulnerability.
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The effects observed in null-mutant mice have been reproduced in wild-type mice after administration of LPA1 antagonist.
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Pharmacological manipulation of LPA/LPA1 pathway could modulate alcohol use.