On the conformational stability of the smallest RNA kissing complexes maintained through two G·C base pairs

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• 作者：Wally Chu ; Akila Weerasekera ; Chul-Hyun Kim ; ^{chul.kim@csueastbay.edu}
• 关键词：RNA structure ; UV melting analysis ; Kissing complex ; Moloney Murine Leukemia Virus ; Dimerization ; Encapsidation
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：39-44
• 全文大小：934 K
• 卷排序：483

文摘

Thermodynamic parameters of the smallest RNA kissing interactions were measured. The effects of loop-closing base pairs on the RNA kissing complex was investigated. Changing the base pair to 5′CG3′ decreases the stability of the kissing complex. Changing it to 5′GC3′ increases the mechanical resilience of the kissing complex. Difference in its stem sequence also affects the stability of the kissing complex.