Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors
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- 作者：Jagdeep Grovera ; Vivek Kumarb ; Vikram Singha ; Khemraj Bairwaa ; M. Elizabeth Sobhiab ; Sanjay M. Jachaka ; sanjayjachak@niper.ac.in" class="auth_mail ; sjachak11@gmail.com" class="auth_mail
- 关键词：Nepodin ; Chrysophanol ; COX inhibitors ; Anti-inflammatory ; Molecular docking
- 刊名：European Journal of Medicinal Chemistry
- 出版年：10 June 2014
- 年：2014
- 卷：80
- 期：Complete
- 页码：47-56
- 全文大小：1399 K
文摘
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Compounds 1f–i, 2e, 2f and 2i were found to be most potent in in vitro assay.
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Compounds 1f, 1g and 2e displayed better anti-inflammatory activity than ibuprofen in vivo.
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Compounds 1f displayed good ADMET profile, similar to naproxen.