Evidence for cell-free nucleic acids as continuously arising endogenous DNA mutagens

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• 作者：Ranjan Basak ; Naveen Kumar Nair ; Indraneel Mittra ; ^{indraneel.mittra@gmail.com}
• 关键词：Cell-free nucleic acids ; Circulating nucleic acids ; Illegitimate genomic integration ; DNA mutagenesis ; DNA damage and apoptosis ; Ageing and cancer
• 刊名：Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：793-794
• 期：Complete
• 页码：15-21
• 全文大小：1080 K
• 卷排序：793

文摘

Circulating cell-free nucleic acids (cfNAs) are readily taken up by healthy cells. The uptaken cfNAs activate DDR and integrate into host cell genomes. Illegitimate genomic integration of cfNAs leads to dsDNA breaks and apoptosis. Consequently, cfNAs act as ubiquitous, physiological, endogenous mutagenic agents. Progressive cfNAs-induced mutagenesis may be implicated in ageing and cancer.