Association of FCGR2A p.R131H and CCL2 c.-2518 A > G gene variants with thrombocytopenia in patients with dengue virus infection

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• 作者：Kalichamy Alagarasu ; ^{alagarasu@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Rupali V. Bachal ; Indraneel Damle ; Paresh S. Shah ; Dayaraj Cecilia
• 关键词：Dengue ; Dengue fever ; Dengue hemorrhagic fever ; Thrombocytopenia ; FCGR2A ; CCL2 ; Gene polymorphisms
• 刊名：Human Immunology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：76
• 期：11
• 页码：819-822
• 全文大小：336 K

文摘

FCGR2A and CCL2 gene variants are important in dengue pathogenesis and were investigated in 122 dengue patients (DENs) [89 dengue fever (DF) and 33 dengue hemorrhagic fever (DHF)] and 107 healthy controls (HCs) to find out their association with severity of dengue. Genotype frequencies of FCGR2A p.R131H and CCL2 c.-2518 A > G polymorphisms were not different between DF, DHF and HC. Significantly higher frequency of R/R genotype of FCGR2A p.R131H was observed in DEN cases with thrombocytopenia (TP) while the G/G genotype of CCL2 c.-2518 A > G was observed only in DEN cases with TP (p < 0.005). These results suggest that FCGR2A and CCL2 gene variants were associated with the risk of TP in dengue infections.