Polyanionic carbosilane dendrimers prevent hepatitis C virus infection in cell culture

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• 作者：Daniel Sepú ; lveda-Crespo ; PhD^a ; ^b ; ^c ; ^d ; ¹ ; José ; Luis Jimé ; nez ; PhD^d ; ⁱ ; ¹ ; Rafael Gó ; mez ; PhD^c ; ^g ; ⁱ ; Francisco Javier De La Mata ; PhD^c ; ^g ; ⁱ ; Pedro L. Majano ; PhD^e ; ^f ; ¹ ; Ma Á ; ngeles Muñ ; oz-Ferná ; ndez ; PhD ; MD^a ; ^b ; ^c ; ^d ; ⁱ ; ; Pablo Gastaminza ; PhD^h ; ^{pgastaminza@cnb.csic.es}
• 关键词：Hepatitis C virus ; Carbosilane dendrimer ; Antiviral ; Nanotechnology ; Virucidal
• 刊名：Nanomedicine: Nanotechnology, Biology and Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：13
• 期：1
• 页码：49-58
• 全文大小：1183 K
• 卷排序：13

文摘

Hepatitis C virus (HCV) infection is a major biomedical problem worldwide. Although new direct antiviral agents (DAAs) have been developed for the treatment of chronic HCV infection, the potential emergence of resistant virus variants and the difficulties to implement their administration worldwide make the development of novel antiviral agents an urgent need. Moreover, no effective vaccine is available against HCV and transmission of the virus still occurs particularly when prophylactic measures are not taken. We used a cell-based system to screen a battery of polyanionic carbosilane dendrimers (PCDs) to identify compounds with antiviral activity against HCV and show that they inhibit effective virus adsorption of major HCV genotypes. Interestingly, one of the PCDs irreversibly destabilized infectious virions. This compound displays additive effect in combination with a clinically relevant DAA, sofosbuvir. Our results support further characterization of these molecules as nanotools for the control of hepatitis C virus spread.