A novel GLP-1 analog, a dimer of GLP-1 via covalent linkage by a lysine, prolongs the action of GLP-1 in the treatment of type 2 diabetes

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• 作者：Yingying Pan^a ; ¹ ; Siwei Shi^b ; ¹ ; Xun Lao^a ; Jinlong Zhang^a ; Shiming Tan^a ; Zirong Wu^a ; Jing Huang^a ; ^{jhuang@bio.ecnu.edu.cn}
• 关键词：GLP-1 analog ; Dimerization ; Type 2 diabetes ; Animal experiment ; Long-term treatment
• 刊名：Peptides
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：88
• 期：Complete
• 页码：46-54
• 全文大小：1881 K
• 卷排序：88

文摘

DLG3312 is a dimer of GLP-1 via covalent linkage by a lysine. DLG3312 remains the native GLP-1 bioactivity and exhibits strong stability in vitro. DLG3312 can efficiently reduce the blood glucose on type 2 diabetes mellitus model mice. The efficacy of DLG3312 in mice is similar to a long-acting marketed drug liragutide.