Association between an interleukin 1 receptor, type I promoter polymorphism and self-reported attentional function in women with breast cancer
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- 作者：John D. Merriman ; Bradley E. Aouizerat ; Janine K. Cataldo ; Laura Dunn ; Bruce A. Cooper ; Claudia West ; Steven M. Paul ; Christina R. Baggott ; An ; Dhruva ; Kord Kober ; Dale J. Langford ; Heather Leutwyler ; Christine S. Ritchie ; Gary Abrams ; Marylin Dodd ; Charles Elboim ; Deborah Hamolsky ; Michelle Melisko ; Christine Miaskowski
- 关键词：AIMs ; ancestry informative markers ; AFI ; Attentional Function Index ; BIC ; Bayesian information criterion ; BMI ; body mass index ; BLRT ; bootstrapped likelihood ratio test ; CI ; confidence interval ; CNS ; central nervous system ; DNA ; deoxyribonucleic acid ; GMM ; growth mixture modeling ; KPS ; Karnofsky Performance Status ; LD ; linkage disequilibrium ; MAF ; minor allele frequency ; OR ; odds ratio ; SCQ ; Self-administered Comorbidity Questionnaire ; SNP ; single nucleotide polymorphism ; VLMR ; Vuong-Lo-Mendell-
- 刊名：Cytokine
- 出版年：February, 2014
- 年：2014
- 卷：65
- 期：2
- 页码：192-201
- 全文大小：536 K
文摘
Subgroups of patients with breast cancer may be at greater risk for cytokine-induced changes in cognitive function after diagnosis and during treatment. The purposes of this study were to identify subgroups of patients with distinct trajectories of attentional function and evaluate for phenotypic and genotypic (i.e., cytokine gene polymorphisms) predictors of subgroup membership. Self-reported attentional function was evaluated in 397 patients with breast cancer using the Attentional Function Index before surgery and for six months after surgery (i.e., seven time points). Using growth mixture modeling, three attentional function latent classes were identified: High (41.6%), Moderate (25.4%), and Low-moderate (33.0%). Patients in the Low-moderate class were significantly younger than those in the High class, with more comorbidities and lower functional status than the other two classes. No differences were found among the classes in years of education, race/ethnicity, or other clinical characteristics. DNA was recovered from 302 patients鈥?samples. Eighty-two single nucleotide polymorphisms among 15 candidate genes were included in the genetic association analyses. After controlling for age, comorbidities, functional status, and population stratification due to race/ethnicity, IL1R1 rs949963 remained a significant genotypic predictor of class membership in the multivariable model. Carrying the rare 鈥淎鈥?allele (i.e., GA + AA) was associated with a twofold increase in the odds of belonging to a lower attentional function class (OR: 1.98; 95% CI: 1.18, 3.30; p = .009). Findings provide evidence of subgroups of women with breast cancer who report distinct trajectories of attentional function and of a genetic association between subgroup membership and an IL1R1 promoter polymorphism.