- 作者：Mollie McDonnold ; Holly Dunn ; Ashley Hester ; Luis D. Pacheco ; Gary D.V. Hankins ; George R. Saade ; Maged M. Costantine
- 关键词：human papilloma virus ; preeclampsia
- 刊名：American Journal of Obstetrics and Gynecology
- 出版年：February, 2014
- 年：2014
- 卷：210
- 期：2
- 页码：138.e1-138.e5
- 全文大小：184 K
Objective
To determine the association between high-risk human papillomavirus (HR-HPV) and preeclampsia.Methods
Retrospective cohort study of women with HR-HPV at entry to prenatal care compared with those with at least 2 normal pap smears. Preeclampsia was defined by clinical guidelines. Unadjusted and adjusted analyses were performed.
Results
Three hundred fourteen women with HR-HPV matched with 628 women with normal pap smears. Exposed HR-HPV patients were younger, had lower body mass index, systolic and diastolic blood pressure at entry to care, and more likely to be nulliparous and smokers. Exposed HR-HPV patients were more likely to develop preeclampsia (10.19% vs 4.94%; P聽= .004; adjusted odds ratio, 2.18; 95% confidence interval, 1.31-3.65). Women with HR-HPV were also more likely to deliver prematurely at less than 37 and less than 35 weeks.
Conclusion
HR-HPV is associated with an almost 2-fold increased risk of developing preeclampsia. This warrants a larger study, particularly when HPV infection can be prevented with vaccination.