Intracellular and extracellular microRNA: An update on localization and biological role

详细信息    查看全文

• 作者：Julia A. Makarova^a ; ^b ; ^{j-makarova@yandex.ru} ; Maxim U. Shkurnikov^a ; Daniel Wicklein^c ; Tobias Lange^c ; Timur R. Samatov^d ; ^e ; Andrey A. Turchinovich^f ; Alexander G. Tonevitsky^a ; ^{tonevitsky@mail.ru}
• 关键词：miRNA ; microRNA ; siRNA ; small interfering RNA ; pRNA ; promoter-associated RNA ; PTGS ; post-transcriptional gene silencing ; RNAi ; RNA interference ; AGO ; argonaute proteins ; RISC ; RNA-induced silencing complexes ; miRISC ; miRNA-induced silencing complexes ; RNP ; the ribonucleoprotein ; ER ; endoplasmic reticulum ; MVB ; multivesicular bodies ; ILV ; intraluminal vesicles ; ESCRT ; endosomal sorting complex required for transport ; HDL ; high-density lipoprotein
• 刊名：Progress in Histochemistry and Cytochemistry
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：51
• 期：3-4
• 页码：33-49
• 全文大小：2157 K
• 卷排序：51

文摘

miRNAs are found in all cellular compartments and regulate various biological processes. A fraction of functional miRNAs is not associated with RISC. miRNAs are secreted from cells by various mechanisms and are involved in cell-cell communication in vivo.