Vacuolar protein sorting mechanisms in apicomplexan parasites

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• 作者：Elena Jimenez-Ruiz^a ; ¹ ; Juliette Morlon-Guyot^b ; ¹ ; Wassim Daher^b ; ^{wassim.daher@univ-montp2.fr} ; Markus Meissner^a ; ^{Markus.Meissner@glasgow.ac.uk}
• 关键词：PM ; plasma membrane ; IMC ; inner membrane complex ; PV ; parasitophorous vacuole ; ER ; endoplasmic reticulum ; TGN ; trans-Golgi network ; ECL ; endosomal-like compartment ; VAC ; vacuolar compartment ; PLV ; plant-like vacuole ; EE ; early endosome ; LE ; late endosome ; MVB ; multi-vesicular body ; VPS ; vacuolar protein sorting ; MTC ; multisubunit tethering complex ; GARP ; Golgi-associated retrograde protein ; ESCRT ; endosomal sorting complex required for transport ; CORVET ; class C core vacuole/endosome tethering
• 刊名：Molecular and Biochemical Parasitology
• 出版年：2016
• 出版时间：September-October 2016
• 年：2016
• 卷：209
• 期：1-2
• 页码：18-25
• 全文大小：1784 K
• 卷排序：209

文摘

The phylum Apicomplexa comprises more than 5000 species including pathogens of clinical and economical importance. These obligate intracellular parasites possess a highly complex endomembrane system to build amongst others three morphologically distinct secretory organelles: rhoptries, micronemes and dense granules. Proteins released by these organelles are essential for invasion and hijacking of the host cell. Due to the complexity of the internal organization of these parasites, a wide panoply of trafficking factors was expected to be required for the correct sorting of proteins towards the various organelles. However, Toxoplasma gondii and other apicomplexan parasites contain only a core set of these factors and several of the vacuolar protein sorting (VPS) homologues found in most eukaryotes have been lost in this phylum.In this review, we will summarise our current knowledge about the role of trafficking complexes in T. gondii, highlighting recent studies focused on complexes formed by VPS proteins. We also present a novel, hypothetical model, suggesting the recycling of parasite membrane and micronemal proteins.